Results 61 to 70 of about 437,562 (315)
HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation
Nature Communications, 2022 Binding to HSP90-CDC37 is essential for the activity of many protein kinases, but its function is unclear. Here, the authors show that HSP90-CDC37 provides a structural platform for the phosphatase PP5 to dephosphorylate a bound kinase, ‘factory ...
Jasmeen Oberoi +6 more
doaj +1 more source
Wellcome Open Research, 2022 Single-molecule localisation microscopy (SMLM) uses software to extract super-resolved positions from microscope images of fluorescent molecules. These localisations can then be used to render super-resolution images or analysed to extract information ...
Antony M. Carr +2 more
doaj +1 more source
The TIMELESS Roles in Genome Stability and Beyond
Journal of Molecular Biology, 2023 TIMELESS protein (TIM) protects replication forks from stalling at difficult-to-replicate regions and plays an important role in DNA damage response, including checkpoint signaling, protection of stalled replication forks and DNA repair. Loss of TIM causes severe replication stress, while its overexpression is common in various types of cancer ...
Sameera Vipat, Tatiana N. Moiseeva
openaire +2 more sources
Stability of the parainfluenza virus 5 genome revealed by deep sequencing of strains isolated from different hosts and following passage in cell culture [PDF]
, 2014 The strain diversity of a rubulavirus, parainfluenza virus 5 (PIV5), was investigated by comparing 11 newly determined and six previously published genome sequences.
Randall, Richard E +10 more
core +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
Nature Communications, 2017 DNA double-strand breaks (DSBs) induced by topoisomerase II (TOP2) are rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promotes or suppresses translocations is not clear. Here the authors show that TDP2 suppresses chromosome
Fernando Gómez-Herreros +6 more
doaj +1 more source
Functional constraint and small insertions and deletions in the ENCODE regions of the human genome. [PDF]
, 2007 BACKGROUND: We describe the distribution of indels in the 44 Encyclopedia of DNA Elements (ENCODE) regions (about 1% of the human genome) and evaluate the potential contributions of small insertion and deletion polymorphisms (indels) to human genetic ...
Cooper, GM +11 more
core +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Acta Medica Bulgarica, 2020 Background and objectives. Though numerous studies have shown that the dysregulation of the epigenetic control is involved in disease manifestation, limited data is available on the transcriptional activity of DNA methylation related genes in alcohol and
Krasteva M. +3 more
doaj +1 more source
Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated Topoisomerase I to promote genome stability [PDF]
, 2013 Peer ...
Alexander Lorenz +16 more
core +1 more source