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The evolution of structural genomics
Biophysical Reviews, 2022 AbstractStructural genomics began as a global effort in the 1990s to determine the tertiary structures of all protein families as a response to large-scale genome sequencing projects. The immediate outcome was an influx of tens of thousands of protein structures, many of which had unknown functions.
Standley, Daron M. +6 more
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Condensed Genome Structure [PDF]
, 2011 Large, tailed dsDNA-containing bacteriophage genomes are packaged to a conserved and high density (∼500 mg/ml), generally in ∼2.5-nm, duplex-to-duplex, spaced, organized DNA shells within icosahedral capsids. Phages with these condensate properties, however, differ markedly in their inner capsid structures: (1) those with a naked condensed DNA, (2 ...
Lindsay W, Black, Julie A, Thomas
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Structural Genomics: Correlation Blocks, Population Structure, and Genome Architecture [PDF]
Current Genomics, 2011 An integration of the pattern of genome-wide inter-site associations with evolutionary forces is important for gaining insights into the genomic evolution in natural or artificial populations. Here, we assess the inter-site correlation blocks and their distributions along chromosomes.
Hu, Xin-Sheng +2 more
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The Role of Protein Structure in Genomics [PDF]
Biochemical Society Transactions, 2000 The genome projects produce an enormous amount of sequence data that needs to be annotated in terms of molecular structure and biological function. These tasks have triggered additional initiatives like structural genomics. The intention is to determine as many protein structures as possible, in the most efficient way, and to exploit the solved ...
Domingues, Francisco S. +2 more
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Structure and Architecture of the Maize Genome [PDF]
Plant Physiology, 2005 Abstract Maize (Zea mays or corn) plays many varied and important roles in society. It is not only an important experimental model plant, but also a major livestock feed crop and a significant source of industrial products such as sweeteners and ethanol.
Haberer, Georg +12 more
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Marrying structure and genomics [PDF]
Structure, 1998 Introduction Today Large-scale genome sequencing is filling up the catalogue of natural proteins at a breathtaking speed. Today, we have available not just a large number of sequences, but also glimpses of the inventory of entire organisms. This information will soon improve our understanding of cells and of life in general. Three means will contribute
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Accounts of Chemical Research, 2002 AbstractFor Abstract see ChemInform Abstract in Full Text.
Staunton, D, Owen, J, Campbell, I
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The success of structural genomics [PDF]
Journal of Structural and Functional Genomics, 2011 The International Conference on Structural Genomics (ICSG 2011, http://sgc.utoronto.ca/ICSG2011/index.php ) [corrected], held in Toronto Canada May 10-14, 2011 was a rich and exciting demonstration of how far structural genomics has come. Structural genomics has now matured into a field that includes both structure and the biology that structure ...
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Making decisions for structural genomics [PDF]
Briefings in Bioinformatics, 2003 A large number of structural genomics programmes have been established worldwide with the common aim of large-scale, high-throughput protein structure determination. Due to the considerable challenges posed by the experimental methods of structural determination (primarily X-ray crystallography and nuclear magnetic resonance spectroscopy) it is ...
Ana P. C. Rodrigues, Roderick E. Hubbard
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Variability in genome structure [PDF]
Nature Methods, 2019 Comparisons of genome organization in many individual cells with high-throughput FISH show extensive variation.
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