Results 31 to 40 of about 1,470,585 (295)

Deciphering the genome structure and paleohistory of _Theobroma cacao_ [PDF]

, 2010
We sequenced and assembled the genome of _Theobroma cacao_, an economically important tropical fruit tree crop that is the source of chocolate. The assembly corresponds to 76% of the estimated genome size and contains almost all previously described ...
Angé, Ange Marie Risterucci, Anne Dievart, Auré, Bertrand Pitollat, Christopher Viot, Claire Lanaud, Cristian Chaparro, Dave Kudrna, Didier Clement, Diogenes Infante, Dominique Brunel, Emmanuel Guiderdoni, Erika Sallet, Florent Murat, Francis Quetier, Francois Sabot, Gaetan Droc, Ismael Kebe, Jean Marc Aury, Jerome Gouzy, Jerome Salse, Jetty Siva S. Ammiraju, John E. Carlson, Jose Fernandes Barbosa-Neto, Joseph Moroh Akaza, Julie Poulain, Karina Gramacho, Laura Gelley, Maguy Rodier-Goud, Manuel Ruiz, Mark Guiltinan, Mathias Tahi, Mathilde Allegre, Melissa Kramer, Michael Abrouk, Michael Axtell, Michel Boccara, Mickael Bourge, Olivier Fouet, Olivier Panaud, Patrick Wincker, Pierre Costet, Rod Wing, Ronan Rivalan, Schiex T., Siela Maximova, Spencer Brown, Stephan C. Schuster, Stephanie Sidibe-Bocs, Thierry Legavre, Valentin Guignon, W. Richard McCombie, Wolfgang Golser, Xavier Argout, Xavier Sabau, Xiang Song, Yolande Roguet, Yufan Zhang, Zhaorong Ma, Zi Sh   +60 more
core   +2 more sources

Immune Regulation in Time and Space: The Role of Local- and Long-Range Genomic Interactions in Regulating Immune Responses

Frontiers in Immunology, 2021
Mammals face and overcome an onslaught of endogenous and exogenous challenges in order to survive. Typical immune cells and barrier cells, such as epithelia, must respond rapidly and effectively to encountered pathogens and aberrant cells to prevent ...
Liam P. Devenish, Musa M. Mhlanga, Musa M. Mhlanga, Musa M. Mhlanga, Yutaka Negishi, Yutaka Negishi, Yutaka Negishi   +6 more
doaj   +1 more source

Elucidating the phylodynamics of endemic rabies virus in eastern Africa using whole-genome sequencing [PDF]

, 2015
Many of the pathogens perceived to pose the greatest risk to humans are viral zoonoses, responsible for a range of emerging and endemic infectious diseases.
Biek, Roman, Brunker, Kirstyn, Cleaveland, Sarah, Fooks, AR, Hampson, Katie, Horton, Daniel L, Kazwala, Rudovick, Lembo, Tiziana, Marston, Denise A, Mtema, Zacharia J, Ngeleja, Chanasa, Sambo, Maganga, Sikana, Lwitiko, Wilkie, Gavin   +13 more
core   +1 more source

Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations [PDF]

, 2014
The HEK293 human cell lineage is widely used in cell biology and biotechnology. Here we use whole-genome resequencing of six 293 cell lines to study the dynamics of this aneuploid genome in response to the manipulations used to generate common 293 cell ...
Boone, Morgane, Callewaert, Nico, Chen, Jason, Drmanac, Radoje, Lambrechts, Diether, Lemmens, Irma, Lin, Yao-Cheng, Meuris, Leander, Moisse, Matthieu, Plaisance, Stéphane, Reumers, Joke, Soete, Arne, Speleman, Franki, Tavernier, Jan, Van de Peer, Yves, Van Roy, Nadine   +15 more
core   +3 more sources

Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review [PDF]

, 2011
A variety of genome-wide profiling techniques are available to probe complementary aspects of genome structure and function. Integrative analysis of heterogeneous data sources can reveal higher-level interactions that cannot be detected based on ...
Akavia, Andrews, Baasiri, Chin, Dai, De Bie, Futreal, H.-U. Klein, Haverty, Hawkins, Hyman, Johnson, Kao, L. Lahti, M. Dugas, M. Schafer, McLendon, Menezes, Mullighan, Mullighan, Myllykangas, Olshen, Ortiz-Estevez, Phillips, Qin, S. Bicciato, Solvang, Soneson, Stranger, van Wieringen, van Wieringen   +30 more
core   +2 more sources

Transcription as a Threat to Genome Integrity [PDF]

, 2016
Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution.
Aguilera López, Andrés, Gaillard, Hélène   +1 more
core   +1 more source

In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus. [PDF]

, 2016
Packaging of the genome into a protein capsid and its subsequent delivery into a host cell are two fundamental processes in the life cycle of a virus. Unlike double-stranded DNA viruses, which pump their genome into a preformed capsid, single-stranded ...
Dai, Xinghong, Du, Yushen, Lai, Mason, Li, Zhihai, Shu, Sara, Sun, Ren, Zhou, Z Hong   +6 more
core   +1 more source

Genomics-aided structure prediction [PDF]

Proceedings of the National Academy of Sciences, 2012
We introduce a theoretical framework that exploits the ever-increasing genomic sequence information for protein structure prediction. Structure-based models are modified to incorporate constraints by a large number of non-local contacts estimated from direct coupling analysis (DCA) of co-evolving genomic sequences.
Sulkowska, Joanna I., Morcos, Faruck, Weigt, Martin, Hwa, Terence, Onuchic, Jose N.   +4 more
openaire   +3 more sources

Rampant exchange of the structure and function of extramembrane domains between membrane and water soluble proteins. [PDF]

, 2013
Of the membrane proteins of known structure, we found that a remarkable 67% of the water soluble domains are structurally similar to water soluble proteins of known structure. Moreover, 41% of known water soluble protein structures share a domain with an
Bowie, James U, Han, Seong Kyu, Kim, Sanguk, Nam, Hyun-Jun   +3 more
core   +3 more sources

Germline-Restricted Chromosome (GRC) in Diploid and Polyploid Spermatocytes of the Eurasian Bullfinch, Pyrrhula pyrrhula (Fringillidae, Passeriformes, Aves)

Animals
The germline-restricted chromosome (GRC) is a unique and enigmatic element found exclusively in the germ cells of passerine birds, with its function and evolutionary dynamics still largely unresolved.
Ekaterina Grishko, Lyubov Malinovskaya, Katerina Tishakova, Pavel Borodin   +3 more
doaj   +1 more source