Results 21 to 30 of about 885,348 (265)

Application of massive parallel sequencing to whole genome SNP discovery in the porcine genome [PDF]

, 2009
Background Although the Illumina 1 G Genome Analyzer generates billions of base pairs of sequence data, challenges arise in sequence selection due to the varying sequence quality.
Kerstens Hindrik HD, Heuven, H.C.M., Johan T den Dunnen, Henri CM Heuven, Andreia J Amaral, den Dunnen Johan T, Dibbits Bert, Groenen Martien AM, Heuven Henri CM, Megens, H.J.W.C., Amaral Andreia J, Megens Hendrik-Jan, Bert Dibbits, Martien AM Groenen, Groenen, M.A.M., Hendrik-Jan Megens, Dibbits, B.W., Dungen, J., den, Kerstens, H.H.D., Hindrik HD Kerstens, Richard PMA Crooijmans, Crooijmans, R.P.M.A., den Dungen, J., Crooijmans Richard PMA, Amaral, A.J.   +24 more
core   +1 more source

Systematic determination of the mosaic structure of bacterial genomes: species backbone versus strain-specific loops [PDF]

, 2005
Background Public databases now contain multitude of complete bacterial genomes, including several genomes of the same species. The available data offers new opportunities to address questions about bacterial genome evolution, a task that requires ...
Petit M-A, El Karoui, Meriem, El Karoui, M, Bourgait, Isabelle, Gendrault-Jacquemard, A, Sourivong, Frédéric, Gendrault, Annie, Gendrault-Jacquemard, Gendrault-Jacquemard A, Chiapello H, Chiapello, H, Sourivong F, Bourgait I, Heuclin G, El Karoui M, El Karoui, Meriem, M., Heuclin, G, Petit, M-A, Bourgait, I, Heuclin, Gaëlle, Chiapello, Helene, Petit, Marie Agnès, Petit, Marie Agnes, M. A., Sourivong, F, Gendrault, Annie   +23 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The complete mitochondrial genome of Yarrowia lipolytica

, 2008
We here report the complete nucleotide sequence of the 47.9 kb mitochondrial (mt) genome from the obligate aerobic yeast Yarrowia lipolytica.
Casaregola, Serge, Durstewitz, Gregor, Brandt, Ulrich, Kerscher, Stefan, Gaillardin, Claude   +4 more
core   +1 more source

Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3' X-tail [PDF]

, 2015
A phylogenetically conserved RNA structure within the NS5B coding region of hepatitis C virus functions as a cis-replicating element (CRE). Integrity of this CRE, designated SL9266 (alternatively 5BSL3.2), is critical for genome replication. SL9266 forms
Struthers, M, Tuplin, AK, Tuplin, Andrew, Bentley, K, Struthers, Madeleine, Cook, J, Cook, Jonathan, Evans, DJ, Evans, David J., Struthers, Madeline, Bentley, Kirsten, Cook, Jonathan P.   +11 more
core   +1 more source

The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081 [PDF]

, 2014
This work was supported by The Wellcome Trust.The human enteropathogen, Yersinia enterocolitica, is a significant link in the range of Yersinia pathologies extending from mild gastroenteritis to bubonic plague.
Maddison, Mark, Abdellah, Zahra, Dougan, Gordon, Howard, Sarah, Quail, Michael A., Parkhill, Julian, Prentice, Michael B., Challis, Gregory L., Mungall, Karen, Chillingworth, Tracey, Moule, Sharon, Sanders, Mandy, Churcher, Carol, Thomson, Nicholas R., Wren, Brendan W., Whitehead, Sally, Brooks, Karen, Jagels, Kay, Feltwell, Theresa, Holden, Matthew T. G., Crossman, Lisa, Hauser, Heidi   +21 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

AGAPE (Automated Genome Analysis PipelinE) for Pan-Genome Analysis of Saccharomyces cerevisiae

, 2015
The characterization and public release of genome sequences from thousands of organ- isms is expanding the scope for genetic variation studies. However, understanding the phenotypic consequences of genetic variation remains a challenge in eukaryotes due
Kisurb Choe, Benjamin J. A. Dickins (703565), Stacia Engel (703566), Barbara Dunn, Barbara Dunn (393141), Janos Demeter (5547), Song Giltae, Giltae Song, Dunn Barbara, Jennifer Gallagher, Cherry, JM, Choe, K, Dickins Benjamin J. A., J. Michael Cherry (5627), Demeter, J, Janos Demeter, Dickins, BJA, Snyder, M, Giltae Song (703564), Song, G, Dunn, B, Benjamin J A Dickins, J Michael Cherry, Gallagher, J, Stacia Engel, Engel, S, Demeter Janos, Michael Snyder, Engel Stacia, Cherry J. Michael   +29 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source