Results 91 to 100 of about 1,403,931 (355)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Towards a robust algorithm to determine topological domains from colocalization data

, 2015
One of the most important tasks in understanding the complex spatial organization of the genome consists in extracting information about this spatial organization, the function and structure of chromatin topological domains from existing experimental ...
Moscalets, Alexander P., Nazarov, Leonid I., Tamm, Mikhail V.   +2 more
core   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Isolation and characterization of the mitochondrial genome of Gymnodraco acuticeps (Perciformes: Bathydraconidae) with phylogenetic consideration

Mitochondrial DNA. Part B. Resources, 2017
Gymnodraco acuticepsis is an Antarctic fish living in the Southern Ocean. Until now, studies on G. acuticeps are still limited. As an Antarctic fish, obtaining and characterization of the mitochondrial genome of G.
Wei Song, Lingzhi Li, Hongliang Huang, Fenfang Chen, Ming Zhao, Keji Jiang, Fengying Zhang, Chunyan Ma, Xuezhong Chen, Lingbo Ma   +9 more
doaj   +1 more source

The gene coding for small ribosomal subunit RNA in the basidiomycete Ustilago maydis contains a group I intron [PDF]

, 1992
The nucleotide sequence of the gene coding for small ribosomal subunit RNA in the basidiomycete Ustilago maydis was determined. It revealed the presence of a group I intron with a length of 411 nucleotides.
De Wachter, Rupert, Goris, Anne, Neefs, Jean-Marc, Van de Peer, Yves   +3 more
core   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Complete plastome sequence of Changiostyrax dolichocarpa (Styracaeae): An endangered (EN) plant species endemic to China

Mitochondrial DNA. Part B. Resources, 2018
Changiostyrax dolichocarpa is a critically endangered plant species occurring in central and southeastern China. Although the systematic position of Changiostyrax was still unclear, morphological characters, plastid and nSSR evidence supported that C ...
Xiu-Lian Cai, Jian-Hua Wang, Kun-Kun Zhao, Zhi-Xin Zhu, Hua-Feng Wang   +4 more
doaj   +1 more source

A Unifying Model of Genome Evolution Under Parsimony [PDF]

, 2014
We present a data structure called a history graph that offers a practical basis for the analysis of genome evolution. It conceptually simplifies the study of parsimonious evolutionary histories by representing both substitutions and double cut and join (
A Bergeron, A Caprara, AE Darling, AW Xu, B Paten, B Paten, B Paten, B Raphael, Benedict Paten, C Chauve, D Bienstock, Daniel R Zerbino, David Haussler, E Tannier, G Bourque, Glenn Hickey, I Elias, J Edmonds, J Felsenstein, J Kim, J Ma, L Chindelevitch, LL Wang, M Alekseyev, M Bader, M Blanchette, M Shao, MD Braga, N El-Mabrouk, N El-Mabrouk, O Westesson, P Medvedev, S Hannenhalli, S Yancopoulos, S Yancopoulos, W Day, W Miller, YS Song   +37 more
core   +3 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Complete plastome sequence of Piper laetispicum (Piperaceae): An endemic plant species in South China

Mitochondrial DNA. Part B. Resources, 2018
Piper laetispicum is dioecious climbers woody with 10 m tall, which is an endemic species in China. It grows on trees or rocks in forests (100–600 m) in Guangdong and Hainan Province of China.
Ming-Tao Wang, Jian-Hua Wang, Kun-Kun Zhao, Zhi-Xin Zhu, Hua-Feng Wang   +4 more
doaj   +1 more source