Results 81 to 90 of about 885,348 (265)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

De novo sequence assembly of Albugo candida reveals a small genome relative to other biotrophic oomycetes [PDF]

, 2011
Background: Albugo candida is a biotrophic oomycete that parasitizes various species of Brassicaceae, causing a disease (white blister rust) with remarkable convergence in behaviour to unrelated rusts of basidiomycete fungi.
Beynon, E., Sillito, Dean, Rays HY Jiang, Sharpe, Andrew G., Jiang, R.H.Y., Dwayne Hegedus, Holub, E., Uzuhashi, S., Hegedus, Dwayne, Matthew G Links, Eric Holub, Beynon, Elena, Holub, E. B., Borhan, M.H., Elena Beynon, Borhan, Mohammad Hossein, Links, Matthew G., Wayne E Clarke, Uzuhashi, Shihomi, Dean Sillito, Links, M.G., Mohammad H Borhan, Clarke, Wayne E., Shihomi Uzuhashi, Jiang, Rays H. Y., Hegedus, D., Clarke, W.E., Sillito, D., Andrew G Sharpe, Sharpe, A.G.   +29 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Genomics and the Human Genome Project

, 2010
This OER consists of an instructional sheet produced by GENIE CETL in the Department of Genetics. By the end of this material you should have learnt about: The genome of an organism i.e.
GENIE CETL
core  

The Amborella genome and the evolution of flowering plants [PDF]

, 2013
Amborella trichopoda is strongly supported as the single living species of the sister lineage to all other extant flowering plants, providing a unique reference for inferring the genome content and structure of the most recent common ancestor (MRCA) of ...
Genome Project, Amborella, Carretero Paulet, Lorenzo   +1 more
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Reassociation kinetics-based approach for partial genome sequencing of the cattle tick, Rhipicephalus (Boophilus) microplus

, 2010
Background: The size and repetitive nature of the Rhipicephalus microplus genome makes obtaining a full genome sequence fiscally and technically problematic. To selectively obtain gene-enriched regions of this tick's genome, Cot filtration was performed,
Matthew Bellgard, Peterson, D., Appolinaire Djikeng, Nene, Vishvanath M., Felix D Guerrero, Guerrero, F.D., Caler, E., Moolhuijzen, Paula, Vishvanath M Nene, Elisabet Caler, Djikeng, Appolinaire, Nene, V.M., Paula Moolhuijzen, Moolhuijzen, P., Shelby Bidwell, Bellgard, M., Daniel G Peterson, Nene, V., Djikeng, A., Guerrero, F., Peterson, D.G., Bidwell, S.   +21 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Tetraploid Wheat Germplasm Diversity Scan based on the Durum Wheat Genome Assembly

, 2018
The genome of modern durum wheat (DW) cultivar Svevo has been assembled based on a combination of whole genome shotgun sequencing (270X), NRGene deNovoMagic assembler, high-resolution genetic mapping obtained from the cross between Svevo DW and Zavitan ...
Raj K Pasam, Silvio Salvi, Hakan Ozkan, Matt Hayden, Simona Corneti, Elisabetta Mazzucotelli, Steven Xu, Curtis Pozniak, The International Durum Wheat Genome Sequencing Consortium, Roberto Tuberosa, Benjamin Kilian, Shiaoman Chao, Elisabetta Frascaroli, Marco Maccaferri, Anna Maria Mastrangelo, Nicola Pecchioni, Luigi Cattivelli, Neils Harris, Reem Joukhadar   +18 more
core  

Draft Genome Sequence of an Escherichia coli O157:H43 Strain Isolated from Cattle

, 2013
Here we report the draft genome sequence of an Escherichia coli O157:H43 strain, designated T22, with an atypical virulence gene profile and isolated from healthy cattle.
Maróti, Gergely, Szűcs, Attila, Sváb, Domonkos, Horváth, Balázs, Tóth, István   +4 more
core   +1 more source