Results 81 to 90 of about 8,437,199 (261)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Recombination and population structure in salmonella enterica [PDF]

, 2011
Salmonella enterica is a bacterial pathogen that causes enteric fever and gastroenteritis in humans and animals. Although its population structure was long described as clonal, based on high linkage disequilibrium between loci typed by enzyme ...
Street, T, Bowden, R., Anjum, Muna F., Xavier Didelot, Falush Daniel, Donnelly Peter, Didelot, X., Anjum, MF, Donelly, P., McVean, G., Gil McVean, Vartul Sangal, Didelot, X, Bowden, Rory, Anjum Muna F., Donnelly, Peter, Anjum, Muna, Achtman, Mark, Sangal, V, Spencer, C., Falush, Daniel, Muna F. Anjum, Sangal, V., Tanya Golubchik, Anjum, M., Achtman, M., Daniel Falush, Peter Donnelly, McVean, G, Didelot, Xavier, Teresa Street, Mark Achtman, Bowden Rory, Spencer, Chris, Didelot Xavier, Sangal, Vartul, Street, T., Spencer Chris, McVean Gil, Spencer, C, Donelly, Peter, Chris Spencer, Donnelly, P, Street, Teresa, Street Teresa, Golubchik Tanya, Golubchik, T., Achtman Mark, Golubchik, Tanya, Falush, D, Rory Bowden, Bowden, R, McVean, Gilean, Sangal Vartul, McVean, Gil, Golubchik, T, Falush, D. ; https://orcid.org/, Muna F Anjum, Achtman, M   +58 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Regional regulation of transcription in the chicken genome [PDF]

, 2010
Background Over the past years, the relationship between gene transcription and chromosomal location has been studied in a number of different vertebrate genomes. Regional differences in gene expression have been found in several different species.
Bastiaansen John WM, Nie, H., Nie Haisheng, Crooijmans, R.P.M.A., Groenen, M.A.M., Groenen Martien AM, Bastiaansen, J.W.M., Crooijmans Richard PMA, Megens, H.J.W.C., Megens Hendrik-Jan   +9 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Systematic determination of the mosaic structure of bacterial genomes: species backbone versus strain-specific loops [PDF]

, 2005
Background Public databases now contain multitude of complete bacterial genomes, including several genomes of the same species. The available data offers new opportunities to address questions about bacterial genome evolution, a task that requires ...
Petit M-A, El Karoui, Meriem, El Karoui, M, Bourgait, Isabelle, Gendrault-Jacquemard, A, Sourivong, Frédéric, Gendrault, Annie, Gendrault-Jacquemard, Gendrault-Jacquemard A, Chiapello H, Chiapello, H, Sourivong F, Bourgait I, Heuclin G, El Karoui M, El Karoui, Meriem, M., Heuclin, G, Petit, M-A, Bourgait, I, Heuclin, Gaëlle, Chiapello, Helene, Petit, Marie Agnès, Petit, Marie Agnes, M. A., Sourivong, F, Gendrault, Annie   +23 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Application of massive parallel sequencing to whole genome SNP discovery in the porcine genome [PDF]

, 2009
Background Although the Illumina 1 G Genome Analyzer generates billions of base pairs of sequence data, challenges arise in sequence selection due to the varying sequence quality.
Kerstens Hindrik HD, Heuven, H.C.M., Johan T den Dunnen, Henri CM Heuven, Andreia J Amaral, den Dunnen Johan T, Dibbits Bert, Groenen Martien AM, Heuven Henri CM, Megens, H.J.W.C., Amaral Andreia J, Megens Hendrik-Jan, Bert Dibbits, Martien AM Groenen, Groenen, M.A.M., Hendrik-Jan Megens, Dibbits, B.W., Dungen, J., den, Kerstens, H.H.D., Hindrik HD Kerstens, Richard PMA Crooijmans, Crooijmans, R.P.M.A., den Dungen, J., Crooijmans Richard PMA, Amaral, A.J.   +24 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source