Results 71 to 80 of about 885,348 (265)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The genome of the obligate intracellular parasite Trachipleistophora hominis : new insights into microsporidian genome dynamics and reductive evolution [PDF]

, 2012
The dynamics of reductive genome evolution for eukaryotes living inside other eukaryotic cells are poorly understood compared to well-studied model systems involving obligate intracellular bacteria.
Thomas Weinmaier (124598), Hall, Neil (Department of Functional and Comparative Genomics, School of Biological Sciences, University of Liverpool), Bernhardt Jörg, Robert P Hirt, Hacker Christian, Swan, Daniel C., Robert P. Hirt (124609), Weinmaier, Thomas, Nakjang, Sirintra, Rattei, Thomas, Harris, Simon R. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Noël Christophe J., Noel, Christophe J., Embley, T. Martin, John M. Lucocq (124603), Christian Hacker (124601), Hirt, Robert P. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Christophe J. Noël (124592), Lucocq, John M., Stephanie Markert, Tom A. Williams, Embley T. Martin, Neil Hall, Nakjang Sirintra, Williams Tom A., Sirintra Nakjang (124590), Dagan Tal, Martin Embley, John M Lucocq, Rattei, Thomas (University of Vienna), Goldberg Alina V., Tom A Williams, Dagan, Tal (Institute for Molecular Evolution, Heinrich Heine University Düsseldorf), Lucocq John M., Hall Neil, Bernhardt, Jörg, Heinz Eva, Simon R. Harris, Neil Hall (12782), Lucocq, John M. (School of Medicine, University of St Andrews), Noël, Christophe J. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Weinmaier, Thomas (University of Vienna), Markert, Stephanie (Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald), Tal Dagan, Daniel C. Swan, Sirintra Nakjang, John M. Lucocq, Dörte Becher, Rattei Thomas, Harris Simon R., Daniel C Swan, Christian Hacker, Thomas Rattei (13991), Becher, Dörte, Swan Daniel C., Heinz, Eva (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Weinmaier Thomas, Eva Heinz, Hacker, Christian, Alina V. Goldberg, Simon R Harris, Christophe J. Noël, Thomas Rattei, Eva Heinz (105025), Swan, Daniel C. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Thomas Weinmaier, Simon R. Harris (124597), Schweder, Thomas (Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald), T Martin Embley, Becher, Doerte, Harris, Simon R., Hacker, Christian (School of Medicine, University of St Andrews), Alina V. Goldberg (124596), Heinz, Eva, Dagan, Tal, Becher Dörte, Markert, Stephanie, Bernhardt, Jörg (Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald), Goldberg, Alina V. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Schweder Thomas, Hirt, Robert P., T. Martin Embley (124611), Nakjang, Sirintra (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Dörte Becher (90765), Tom A. Williams (124587), Thomas Schweder (124606), Markert Stephanie, Bernhardt, Joerg, Embley, T. Martin (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Williams, Tom A., Hirt Robert P., Alina V Goldberg, Williams, Tom A. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Jörg Bernhardt (124600), Jörg Bernhardt, Goldberg, Alina V., Schweder, Thomas, Tal Dagan (68513), Robert P. Hirt, Lucocq, John Milton, Hall, Neil, Christophe J Noël, Thomas Schweder, Becher, Dörte (Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald), Daniel C. Swan (124594), Stephanie Markert (124599)   +105 more
core   +1 more source

The structure of genomes [PDF]

Genome Biology, 2000
The particular interest of David Ussery and his group is in creating 'structural atlases' of genomes from a detailed analysis of variations in DNA structure.
openaire   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Improved heritability estimation from genome-wide SNPs

, 2012
Narrow-sense heritability (h(2)) is an important genetic parameter that quantifies the proportion of phenotypic variance in a trait attributable to the additive genetic variation generated by all causal variants.
Johnson, Michael R., Balding, DJ, Hemani, G, Hemani, Gibran, Balding, David J., Speed, D, Johnson, MR, Speed, Doug   +7 more
core   +1 more source

Structural genomics on the web.

Comparative and functional genomics, 2001
In this review we provide a brief guide to some of the resources and databases that can be used to locate information and aid research in the growing field of structural genomics. The review will provide examples, for less experienced users, of what can be achieved using a selection of the available sites.
openaire   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Thermodynamic pathways to genome spatial organization in the cell nucleus [PDF]

, 2009
The architecture of the eukaryotic genome is characterized by a high degree of spatial organization. Chromosomes occupy preferred territories correlated to their state of activity and, yet, displace their genes to interact with remote sites in complex ...
A. Prisco, Prisco, Antonella, Nicodemi, Mario   +2 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source