Results 91 to 100 of about 885,348 (265)

Bioinformatics in structural genomics [PDF]

Bioinformatics, 2002
Burkhard, Rost, Barry, Honig, Alfonso, Valencia   +2 more
openaire   +2 more sources

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

The complexity of Rhipicephalus (Boophilus) microplus genome characterised through detailed analysis of two BAC clones

, 2011
Background Rhipicephalus (Boophilus) microplus (Rmi) a major cattle ectoparasite and tick borne disease vector, impacts on animal welfare and industry productivity.
Peterson, D., Morgan Jess A T, Moolhuijzen, Paula M., Moolhuijzen, P.M., Dowd, S.E, Peterson, Daniel G., Bellgard, Matthew I., Bellgard Matthew I, Dowd Scot E, Bellgard, M.I., Appels, Rudi, Peterson Daniel G, Daniel G Peterson, Manuel Valle, Guerrero, F., Lew-Tabor, Ala E., Paula M Moolhuijzen, Valle, M.R., Appels Rudi, Moolhuijzen Paula M, Felix D Guerrero, Lew-Tabor, A.E., Lew-Tabor Ala E, Manuel Rodriguez Valle, Guerrero, F.D., Matthew I Bellgard, Lew-Tabor, A., Valle, Manuel Rodriguez, Guerrero Felix D, Moolhuijzen, Paula, Dowd, Scot E., Morgan, J.A.T., Dowd, S., Morgan, J., Valle, M., Bellgard, M., Scot E Dowd, Valle Manuel, Jess A T Morgan, Peterson, D.G., Appels, R., Rudi Appels, Ala E Lew-Tabor, Morgan, Jess A.T., Guerrero, Felix D.   +44 more
core   +1 more source

Accurate prediction of genome-wide RNA secondary structure profile based on extreme gradient boosting

, 2020
For permissions, please e-mail: journals.permissions@oup.com Motivation: RNA secondary structure plays a vital role in fundamental cellular processes, and identification of RNA secondary structure is a key step to understand RNA functions.
Xiao, N, Rao, J, Ke, Y, Jiahua Rao, Yutong Lu, Lu, Y, Yuedong Yang, Huiying Zhao, Zhao, H, Yang, Y, Nong Xiao, Yaobin Ke   +11 more
core   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype

, 2009
Whereas most nontyphoidal Salmonella (NTS) are associated with gastroenteritis, there has been a dramatic increase in reports of NTS-associated invasive disease in sub-Saharan Africa. Salmonella enterica serovar Typhimurium isolates are responsible for a
Clarke, L., Molyneux, M., Molyneux, Malcolm, MacLennan, CA, Molyneux, Malcom E., Gordon, M. A., Kariuki, Samuel, Cormican, M., Parkhill, J, Holt, Kathryn E., Thomson, N., Kingsley, Robert, Harris, D., Whitehead, Sally, Heyderman, R., Kariuki, S., Thomson, N. R., MacLennan, Calman A., Whitehead, S., Achtman, Mark, Sangal, V, Molyneux, ME, Msefula, CL, Sangal, V., Marsh, K., Holt, K. E., Kariuki, S, Thomson, Nicholas R., MacLennan, Calman, Clarke, L, Achtman, M., Gordon, Melita A., MacLennan, C. A., Holt, Kathryn, Gordon, M., Heyderman, R. S., Dougan, G., Gordon, Melita, Sangal, Vartul, Holt, K., Msefula, C., Msefula, Chisomo, Cormican, Martin, Holt, KE, Parkhill, J., Kingsley, R., Msefula, C. L., Msefula, Chisomo L., Marsh, K, Kingsley, RA, Kingsley, Robert A., Dougan, Gordon, Kingsley, R. A., Parkhill, Julian, Gordon, MA, Thomson, Nicholas, Whitehead, S, Harris, D, Molyneux, M. E., Heyderman, RS, Heyderman, Robert S., Harris, David, Marsh, Kevin, MacLennan, C., Clarke, Louise, Dougan, G, Heyderman, Robert, Thomson, NR, Achtman, M, Cormican, M   +69 more
core   +1 more source

Structure and the genome [PDF]

Nature Structural & Molecular Biology, 1997
openaire   +2 more sources