Results 101 to 110 of about 1,478,279 (326)
Marrying structure and genomics [PDF]
Structure, 1998 Introduction Today Large-scale genome sequencing is filling up the catalogue of natural proteins at a breathtaking speed. Today, we have available not just a large number of sequences, but also glimpses of the inventory of entire organisms. This information will soon improve our understanding of cells and of life in general. Three means will contribute
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Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Variability in genome structure [PDF]
Nature Methods, 2019 Comparisons of genome organization in many individual cells with high-throughput FISH show extensive variation.
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Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Comparison of hom(oe)ologous chromosome segments in the highly polyploid interspecific genome of sugarcane [PDF]
, 2013 Modern sugarcane cultivars (Saccharum spp.) present one of the most complex crop genome studied to date, mainly due to a very high degree of polyploidy (2n = 12x = 120), and an interspecific origin from two autopolyploid species, namely S.
Charron, Carine +5 more
core
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
High homologous gene conservation despite extreme autopolyploid redundancy in sugarcane [PDF]
, 2011 Modern sugarcane (Saccharum spp.) has been recognized as one of the world's most efficient crops in solar energy conversion and as havlng the mast favorable input: output ratios. Beside ils importance for sugar production, ilthus became recently aprimary
Bocs, Stéphanie +5 more
core
Genome-Wide SNP Analysis Reveals the Genetic Diversity and Population Structure of the Domestic Reindeer Population (Rangifer tarandus) Inhabiting the Indigenous Tofalar Lands of Southern Siberia [PDF]
, 2022 В. Р. Харзинова +6 more
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Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source