Results 111 to 120 of about 1,478,279 (326)
Genome-based structural biology
Progress in Biophysics and Molecular Biology, 1999 Spectacular achievements in whole genome sequencing open up new possibilities for structural research. Protein structures can now be studied in their natural genomic context. On the other hand, structure prediction algorithms can be improved using species-specific tendencies in folding patterns.
D, Frishman, H W, Mewes
openaire +2 more sources
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Role of HIV RNA structure in recombination and speciation: romping in purine A, keeps HTLV away
, 2013 Extreme enrichment of the human immunodeficiency virus (HIV-1) RNA genome for the purine A parallels the mild purine-loading of the RNAs of most organisms.
Forsdyke, Donald R.
core +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Complete plastome sequence of Stauntonia obovatifoliola subsp. urophylla (Lardizabalaceae)
Mitochondrial DNA. Part B. Resources, 2019 Stauntonia obovatifoliola subsp. urophylla belongs to Lardizabalaceae. It is woody vine, with fine lines on its stems, branches, and petioles. In China, they are mainly distributed in Fujian, Guangdong, Guangxi, Jiangxi, Hunan, and Zhejiang.
Hua-Min Huang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
High-Resolution Genome-wide Mapping of the Primary Structure of Chromatin [PDF]
, 2011 Zhenhai Zhang, B. Franklin Pugh
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Deep genome‐wide phylogeographic structure indicates cryptic diversity in the Middle Spotted Woodpecker (Dendrocoptes medius) [PDF]
, 2022 Manuel Schweizer +8 more
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