Results 21 to 30 of about 1,478,279 (326)

Rampant exchange of the structure and function of extramembrane domains between membrane and water soluble proteins. [PDF]

, 2013
Of the membrane proteins of known structure, we found that a remarkable 67% of the water soluble domains are structurally similar to water soluble proteins of known structure. Moreover, 41% of known water soluble protein structures share a domain with an
Bowie, James U, Han, Seong Kyu, Kim, Sanguk, Nam, Hyun-Jun   +3 more
core   +3 more sources

Patterns of genetic diversity and linkage disequilibrium in a highly structured Hordeum vulgare association-mapping population for the Mediterranean basin [PDF]

, 2009
Population structure and genome-wide linkage disequilibrium (LD) were investigated in 192 Hordeum vulgare accessions providing a comprehensive coverage of past and present barley breeding in the Mediterranean basin, using 50 nuclear microsatellite and 1 ...
Akar, T., Al-Yassin, A., Benbelkacem, A., Bort, J., Ceccarelli, S., Comodran, J., Eeuwijk, F.A., van, Grando, S., Hackett, C.A., Ouabbou, H., Pecchioni, N., Romagosa, I., Russel, J.R., Stanca, A.M., Thomas, W.T.B.   +14 more
core   +2 more sources

Locus specific engineering of tandem DNA repeats in the genome of Saccharomyces cerevisiae using CRISPR/Cas9 and overlapping oligonucleotides

Scientific Reports, 2018
DNA repeats constitute a large part of genomes of multicellular eucaryotes. For a longtime considered as junk DNA, their role in genome organization and tuning of gene expression is being increasingly documented.
Astrid Lancrey, Alexandra Joubert, Jean-Baptiste Boulé   +2 more
doaj   +1 more source

Immune Regulation in Time and Space: The Role of Local- and Long-Range Genomic Interactions in Regulating Immune Responses

Frontiers in Immunology, 2021
Mammals face and overcome an onslaught of endogenous and exogenous challenges in order to survive. Typical immune cells and barrier cells, such as epithelia, must respond rapidly and effectively to encountered pathogens and aberrant cells to prevent ...
Liam P. Devenish, Musa M. Mhlanga, Musa M. Mhlanga, Musa M. Mhlanga, Yutaka Negishi, Yutaka Negishi, Yutaka Negishi   +6 more
doaj   +1 more source

Complex patterns of local adaptation in teosinte [PDF]

, 2012
Populations of widely distributed species often encounter and adapt to specific environmental conditions. However, comprehensive characterization of the genetic basis of adaptation is demanding, requiring genome-wide genotype data, multiple sampled ...
Barthakur, Beaumont, Beaumont, Bomblies, Bradburd, Bradbury, Buckler, Chalker-Scott, Charlesworth, Cheng, Chia, Clausen, Cook, Coop, Cutter, De, Dobzhansky, Doebley, Doyle, Earl, Eckert, Eckert, Endler, Etges, Excoffier, Excoffier, Falush, Fang, Feder, Flint-Garcia, Foll, Ford, Fournier-Level, Fukunaga, Fumagalli, Galinat, Ganal, Gerke, Gore, Goudet, Grant, Green, Gregory, Gusev, Hancock, Hancock, Hijmans, Hufford, Hufford, Hufford, Hufford, Hung, Huynh, Iltis, Jackson, Jeffrey Ross-Ibarra, Kato, Kato, Keller, Kirkpatrick, Kirkpatrick, Lauter, Le Corre, Lewontin, Li, Loveless, Lowry, Lowry, Mano, Mathieson, Matthew B. Hufford, Medina, Meyerowitz, Moeller, Moeller, Oksanen, Olsson, Patterson, Platt, Poggio, R Core Team, Rosenberg, Ross-Ibarra, Saghai-Maroof, Salvi, Sanchez, Scheet, Schnable, Sheldon, Siol, Smith, Smith, Sofiane Mezmouk, St. Onge, Storz, Studer, Städler, Tanja Pyhäjärvi, Ting, Toomajian, Turner, Turner, van Heerwaarden, van Heerwaarden, Wang, Weber, Weber, Weir, Wilkes, Wolfgruber, Wright, Yang   +111 more
core   +2 more sources

The respiratory syncytial virus nucleoprotein–RNA complex forms a left-handed helical nucleocapsid [PDF]

, 2013
Respiratory Syncytial Virus (RSV) is an important human pathogen. Its nucleocapsid (NC), which comprises the negative sense RNA viral genome coated by the viral nucleoprotein N, is a critical assembly that serves as template for both mRNA synthesis and ...
Bhella, Colin Loney, David Bhella, Edward Conner, Egelman, Fix, Félix A. Rey, Jean-François Eléouët, Marie Galloux, Saskia E. Bakker, Stéphane Duquerroy   +10 more
core   +3 more sources

Is HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably? [PDF]

, 2004
During virus assembly, all retroviruses specifically encapsidate two copies of full-length viral genomic RNA in the form of a non-covalently linked RNA dimer.
Liang, Chen, Russell, Rodney S, Wainberg, Mark A   +2 more
core   +3 more sources

Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review [PDF]

, 2011
A variety of genome-wide profiling techniques are available to probe complementary aspects of genome structure and function. Integrative analysis of heterogeneous data sources can reveal higher-level interactions that cannot be detected based on ...
Akavia, Andrews, Baasiri, Chin, Dai, De Bie, Futreal, H.-U. Klein, Haverty, Hawkins, Hyman, Johnson, Kao, L. Lahti, M. Dugas, M. Schafer, McLendon, Menezes, Mullighan, Mullighan, Myllykangas, Olshen, Ortiz-Estevez, Phillips, Qin, S. Bicciato, Solvang, Soneson, Stranger, van Wieringen, van Wieringen   +30 more
core   +2 more sources

Structure of the herpes-simplex virus portal-vertex [PDF]

, 2018
Herpesviruses include many important human pathogens such as herpes simplex virus, cytomegalovirus, varicella-zoster virus, and the oncogenic Epstein–Barr virus and Kaposi sarcoma–associated herpesvirus.
Bhella, David, McElwee, Marion, Rixon, Frazer, Vijayakrishnan, Swetha   +3 more
core   +2 more sources

Genomics-aided structure prediction [PDF]

Proceedings of the National Academy of Sciences, 2012
We introduce a theoretical framework that exploits the ever-increasing genomic sequence information for protein structure prediction. Structure-based models are modified to incorporate constraints by a large number of non-local contacts estimated from direct coupling analysis (DCA) of co-evolving genomic sequences.
Sulkowska, Joanna I., Morcos, Faruck, Weigt, Martin, Hwa, Terence, Onuchic, Jose N.   +4 more
openaire   +3 more sources