Results 21 to 30 of about 1,458,740 (176)

Locus specific engineering of tandem DNA repeats in the genome of Saccharomyces cerevisiae using CRISPR/Cas9 and overlapping oligonucleotides

Scientific Reports, 2018
DNA repeats constitute a large part of genomes of multicellular eucaryotes. For a longtime considered as junk DNA, their role in genome organization and tuning of gene expression is being increasingly documented.
Astrid Lancrey, Alexandra Joubert, Jean-Baptiste Boulé   +2 more
doaj   +1 more source

Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review [PDF]

, 2011
A variety of genome-wide profiling techniques are available to probe complementary aspects of genome structure and function. Integrative analysis of heterogeneous data sources can reveal higher-level interactions that cannot be detected based on ...
Akavia, Andrews, Baasiri, Chin, Dai, De Bie, Futreal, H.-U. Klein, Haverty, Hawkins, Hyman, Johnson, Kao, L. Lahti, M. Dugas, M. Schafer, McLendon, Menezes, Mullighan, Mullighan, Myllykangas, Olshen, Ortiz-Estevez, Phillips, Qin, S. Bicciato, Solvang, Soneson, Stranger, van Wieringen, van Wieringen   +30 more
core   +2 more sources

Immune Regulation in Time and Space: The Role of Local- and Long-Range Genomic Interactions in Regulating Immune Responses

Frontiers in Immunology, 2021
Mammals face and overcome an onslaught of endogenous and exogenous challenges in order to survive. Typical immune cells and barrier cells, such as epithelia, must respond rapidly and effectively to encountered pathogens and aberrant cells to prevent ...
Liam P. Devenish, Musa M. Mhlanga, Musa M. Mhlanga, Musa M. Mhlanga, Yutaka Negishi, Yutaka Negishi, Yutaka Negishi   +6 more
doaj   +1 more source

Single-molecule real-time sequencing combined with optical mapping yields completely finished fungal genome [PDF]

, 2015
Next-generation sequencing (NGS) technologies have increased the scalability, speed, and resolution of genomic sequencing and, thus, have revolutionized genomic studies.
Datema, Erwin, Faino, Luigi, Janssen, Antoine, Seidl, Michael F., Thomma, Bart P. H. J., Van Den Berg, Grardy C. M., Wittenberg, Alexander H. J.   +6 more
core   +2 more sources

Genes in the postgenomic era [PDF]

, 2006
We outline three very different concepts of the gene - 'instrumental', 'nominal', and 'postgenomic'. The instrumental gene has a critical role in the construction and interpretation of experiments in which the relationship between genotype and phenotype ...
B. Alberts, B. Alberts, C. Finta, C. Kenneth Waters, C. Kenneth Waters, C. Kenneth Waters, D. Communi, D. Kampa, E.M. Neumann-Held, Frederic L. Holmes, G. Stent, George C Williams, Karola Stotz, Karola Stotz, Karola Stotz, Kim Sterelny, Lenny Moss, M Burian Richard, M.W Gray, Marcel Weber, Michael Morange, Michael R Dietrich, Michael R Dietrich, Niall Dillon, P. Kapranov, P.S.R. Coelho, Paul E. Griffiths, Pavel V. Baranov, Petter Portin, Raphael Falk, Raphael Falk, Richard Dawkins, Richard Dawkins, Robert C Olby, T. Blumenthal, Thomas Hunt Morgan, Thomas Kuhn, Thomas. Fogle, Y. Chapdelaine   +38 more
core   +2 more sources

The respiratory syncytial virus nucleoprotein–RNA complex forms a left-handed helical nucleocapsid [PDF]

, 2013
Respiratory Syncytial Virus (RSV) is an important human pathogen. Its nucleocapsid (NC), which comprises the negative sense RNA viral genome coated by the viral nucleoprotein N, is a critical assembly that serves as template for both mRNA synthesis and ...
Bhella, Colin Loney, David Bhella, Edward Conner, Egelman, Fix, Félix A. Rey, Jean-François Eléouët, Marie Galloux, Saskia E. Bakker, Stéphane Duquerroy   +10 more
core   +3 more sources

Complex patterns of local adaptation in teosinte [PDF]

, 2012
Populations of widely distributed species often encounter and adapt to specific environmental conditions. However, comprehensive characterization of the genetic basis of adaptation is demanding, requiring genome-wide genotype data, multiple sampled ...
Barthakur, Beaumont, Beaumont, Bomblies, Bradburd, Bradbury, Buckler, Chalker-Scott, Charlesworth, Cheng, Chia, Clausen, Cook, Coop, Cutter, De, Dobzhansky, Doebley, Doyle, Earl, Eckert, Eckert, Endler, Etges, Excoffier, Excoffier, Falush, Fang, Feder, Flint-Garcia, Foll, Ford, Fournier-Level, Fukunaga, Fumagalli, Galinat, Ganal, Gerke, Gore, Goudet, Grant, Green, Gregory, Gusev, Hancock, Hancock, Hijmans, Hufford, Hufford, Hufford, Hufford, Hung, Huynh, Iltis, Jackson, Jeffrey Ross-Ibarra, Kato, Kato, Keller, Kirkpatrick, Kirkpatrick, Lauter, Le Corre, Lewontin, Li, Loveless, Lowry, Lowry, Mano, Mathieson, Matthew B. Hufford, Medina, Meyerowitz, Moeller, Moeller, Oksanen, Olsson, Patterson, Platt, Poggio, R Core Team, Rosenberg, Ross-Ibarra, Saghai-Maroof, Salvi, Sanchez, Scheet, Schnable, Sheldon, Siol, Smith, Smith, Sofiane Mezmouk, St. Onge, Storz, Studer, Städler, Tanja Pyhäjärvi, Ting, Toomajian, Turner, Turner, van Heerwaarden, van Heerwaarden, Wang, Weber, Weber, Weir, Wilkes, Wolfgruber, Wright, Yang   +111 more
core   +2 more sources

Genomics-aided structure prediction [PDF]

Proceedings of the National Academy of Sciences, 2012
We introduce a theoretical framework that exploits the ever-increasing genomic sequence information for protein structure prediction. Structure-based models are modified to incorporate constraints by a large number of non-local contacts estimated from direct coupling analysis (DCA) of co-evolving genomic sequences.
Sulkowska, Joanna I., Morcos, Faruck, Weigt, Martin, Hwa, Terence, Onuchic, Jose N.   +4 more
openaire   +3 more sources

Germline-Restricted Chromosome (GRC) in Diploid and Polyploid Spermatocytes of the Eurasian Bullfinch, Pyrrhula pyrrhula (Fringillidae, Passeriformes, Aves)

Animals
The germline-restricted chromosome (GRC) is a unique and enigmatic element found exclusively in the germ cells of passerine birds, with its function and evolutionary dynamics still largely unresolved.
Ekaterina Grishko, Lyubov Malinovskaya, Katerina Tishakova, Pavel Borodin   +3 more
doaj   +1 more source

Lessons from Structural Genomics [PDF]

Annual Review of Biophysics, 2009
A decade of structural genomics, the large-scale determination of protein structures, has generated a wealth of data and many important lessons for structural biology and for future large-scale projects. These lessons include a confirmation that it is possible to construct large-scale facilities that can determine the structures of a hundred or more ...
Thomas C, Terwilliger, David, Stuart, Shigeyuki, Yokoyama   +2 more
openaire   +2 more sources