Results 11 to 20 of about 188,489 (201)

Integrating Transcriptome-Wide Association Study and mRNA Expression Profiling Identifies Novel Genes Associated With Osteonecrosis of the Femoral Head

Frontiers in Genetics, 2021
ObjectiveThis study aims to identify novel candidate genes associated with osteonecrosis of the femoral head (ONFH).MethodsA transcriptome-wide association study (TWAS) was performed by integrating the genome-wide association study dataset of ...
Mei Ma, Peilin Li, Li Liu, Shiqiang Cheng, Bolun Cheng, Chu Jun Liang, Sijia Tan, Wenyu Li, Yan Wen, Xiong Guo, Cuiyan Wu   +10 more
doaj   +1 more source

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci

Breast Cancer Research, 2022
Background Mammographic density (MD) phenotypes, including percent density (PMD), area of dense tissue (DA), and area of non-dense tissue (NDA), are associated with breast cancer risk. Twin studies suggest that MD phenotypes are highly heritable. However,
Hongjie Chen, Shaoqi Fan, Jennifer Stone, Deborah J. Thompson, Julie Douglas, Shuai Li, Christopher Scott, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Christopher Li, Ulrike Peters, John L. Hopper, Melissa C. Southey, Tu Nguyen-Dumont, Tuong L. Nguyen, Peter A. Fasching, Annika Behrens, Gemma Cadby, Rachel A. Murphy, Kristan Aronson, Anthony Howell, Susan Astley, Fergus Couch, Janet Olson, Roger L. Milne, Graham G. Giles, Christopher A. Haiman, Gertraud Maskarinec, Stacey Winham, Esther M. John, Allison Kurian, Heather Eliassen, Irene Andrulis, D. Gareth Evans, William G. Newman, Per Hall, Kamila Czene, Anthony Swerdlow, Michael Jones, Marina Pollan, Pablo Fernandez-Navarro, Daniel S. McConnell, Vessela N. Kristensen, NBCS Investigators, Joseph H. Rothstein, Pei Wang, Laurel A. Habel, Weiva Sieh, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Gretchen L. Gierach, Rulla M. Tamimi, Celine M. Vachon, Sara Lindström   +56 more
doaj   +1 more source

Genome-Wide Association Study (GWAS) of Mesocotyl Length for Direct Seeding in Rice

Agronomy, 2021
Direct seeding is considered an efficient cultivation technology that reduces water use and labor costs. Mesocotyl length is one of the significant traits in cultivation; long mesocotyl is beneficial for the rate and uniformity of seedling emergence.
Seong-Gyu Jang, So-Yeon Park, San Mar Lar, Hongjia Zhang, Ah-Rim Lee, Fang-Yuan Cao, Jeonghwan Seo, Tae-Ho Ham, Joohyun Lee, Soon-Wook Kwon   +9 more
doaj   +1 more source

Transcriptome-wide association study identifies susceptibility genes for rheumatoid arthritis

Arthritis Research & Therapy, 2021
Objective To identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS) and gene expression profile data. Methods A transcriptome-wide association study (TWAS) was conducted by
Cuiyan Wu, Sijian Tan, Li Liu, Shiqiang Cheng, Peilin Li, Wenyu Li, Huan Liu, Feng’e Zhang, Sen Wang, Yujie Ning, Yan Wen, Feng Zhang   +11 more
doaj   +1 more source

Unifying candidate gene and GWAS Approaches in Asthma. [PDF]

, 2010
The first genome wide association study (GWAS) for childhood asthma identified a novel major susceptibility locus on chromosome 17q21 harboring the ORMDL3 gene, but the role of previous asthma candidate genes was not specifically analyzed in this GWAS ...
Berg, Andrea von, Bufe, Albrecht, Depner, Martin, Frischer, Thomas, Genuneit, Jon, Gut, Ivo G., Heinzmann, Andrea, Illig, Thomas, Kabesch, Michael, Klopp, Norman, Kumar, Ashish, Lathrop, Mark, Laub, Otto, Liang, Liming, Michel, Sven, Mutius, Erika von, Rietschel, Ernst, Ruether, Andreas, Schedel, Michaela, Schreiber, Stefan, Simma, Burkhard, Vogelberg, Christian   +21 more
core   +10 more sources

Genome-Wide Association Study Identifies Loci for Liver Enzyme Concentrations in Mexican Americans: The GUARDIAN Consortium. [PDF]

, 2019
ObjectivePopulations of Mexican American ancestry are at an increased risk for nonalcoholic fatty liver disease. The objective of this study was to determine whether loci in known and novel genes were associated with variation in aspartate ...
Chen, Yii-Der I, Fingerlin, Tasha E, Goodarzi, Mark O, Guo, Xiuqing, Langefeld, Carl D, Norris, Jill M, Palmer, Nicholette D, Raffel, Leslie J, Rotter, Jerome I, Taylor, Kent D, Wagenknecht, Lynne E, Wang, Nan, Watanabe, Richard M, Williams, Adrienne H, Xiang, Anny H, Young, Kendra A   +15 more
core   +2 more sources

Genome-wide association study of quality traits and starch pasting properties of maize kernels

BMC Genomics, 2023
Background Starch are the main nutritional components of maize (Zea mays L.), and starch pasting properties are widely used as essential indicators for quality estimation.
Xinmei Guo, Zhaopeng Ge, Ming Wang, Meiai Zhao, Yuhe Pei, Xiyun Song   +5 more
doaj   +1 more source

Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans [PDF]

, 2016
INTRODUCTION: African Americans' (AAs) late-onset Alzheimer's disease (LOAD) genetic risk profile is incompletely understood. Including clinical covariates in genetic analyses using informed conditioning might improve study power.
, Barnes, Lisa L., Bennett, David A., Bourlas, Alexandra P., Buxbaum, Joseph D., Byrd, Goldie S., Chung, Jaeyoon, Crane, Paul K., Ertekin-Taner, Nilüfer, Evans, Denis, Fallin, M. Daniele, Farrer, Lindsay A., Foroud, Tatiana, Goate, Alison, Graff-Radford, Neill R., Haines, Jonathan L., Hall, Kathleen S., Jun, Gyungah, Kamboh, M. Ilyas, Kriegel, Joshua, Kukull, Walter A., Larson, Eric B., Logue, Mark W., Lunetta, Kathryn L., Manly, Jennifer J., Mayeux, Richard, Mez, Jesse, Pericak-Vance, Margaret A., Schellenberg, Gerard D., Sherva, Richard   +29 more
core   +1 more source

nf-gwas-pipeline: A Nextflow Genome-Wide Association Study Pipeline [PDF]

Journal of Open Source Software, 2021
A tool for conducting Genome-Wide Association Study (GWAS) in a systematic, automated and reproducible manner is overdue. We developed an automated GWAS pipeline by combining multiple analysis tools - including bcftools, vcftools, the R packages SNPRelate/GENESIS/GMMAT and ANNOVAR - through Nextflow, which is a portable, flexible, and reproducible ...
Song, Zeyuan, Gurinovich, Anastasia, Federico, Anthony, Monti, Stefano, Sebastiani, Paola   +4 more
openaire   +2 more sources

Genome-wide associate study identifies five new schizophrenia loci [PDF]

, 2011
We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent ...
The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium
core   +2 more sources