Results 21 to 30 of about 121,324 (217)

Genome-wide association analysis to identify QTL for carcass traits in Hanwoo (Korean native cattle)

Indian Journal of Animal Sciences, 2019
A genome-wide association study (GWAS) was performed to investigate the genetic markers associated with carcass traits of Hanwoo (Bos taurus coreanae) steer in the Gangwon region of Korea.
MIN-WOOK HONG, SO-YOUNG CHOI, NARESH KUMAR SINGH, HUN KIM, SONG-YI YANG, KYEONGROK KWAK, JONG-BOK KIM, SUNG-JIN LEE   +7 more
doaj   +1 more source

Precision Medicine Needs to Think Outside the Box

Frontiers in Genetics, 2022
Precision medicine offers a precious opportunity to change clinical practice and disrupt medicine’s reliance on crude racial, ethnic, or ancestral categories by focusing on an individual’s unique genetic, environmental, and lifestyle characteristics ...
Daphne O. Martschenko, Jennifer L. Young, Jennifer L. Young   +2 more
doaj   +1 more source

Genome-wide association study and subsequent functional analysis reveal regulatory mechanism underlying piglet diarrhea [PDF]

Animal Bioscience
Objective Piglet diarrhea poses a serious threat to piglet health and the livestock economy, and is one of the most pressing problems in animal husbandry.
Dong Chen, Qi Shen, Rui Huang, Zhenjian Zhao, Yang Yu, Shengdi Cui, Junge Wang, Ziyang Chen, Pingxian Wu, Guoqing Tang   +9 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Deciphering the Genetic Basis of Allelopathy in japonica Rice Cultivated in Temperate Regions Using a Genome-Wide Association Study

Rice
Allelopathy has been considered as a natural method of weed control. Despite the nature of allelochemical compounds has been studied, little is known about the genetic basis underlying allelopathy.
Julia García-Romeral, Raúl Castanera, Josep Casacuberta, Concha Domingo   +3 more
doaj   +1 more source

Genome-Wide Association Studies of Maize Seedling Root Traits under Different Nitrogen Levels

Plants, 2022
Nitrogen (N) is one of the important factors affecting maize root morphological construction and growth development. An association panel of 124 maize inbred lines was evaluated for root and shoot growth at seedling stage under normal N (CK) and low N ...
Yafang Fu, Jianchao Liu, Zhenqing Xia, Qi Wang, Shibo Zhang, Guixin Zhang, Haidong Lu   +6 more
doaj   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Identification of hub genes regulating isoflavone accumulation in soybean seeds via GWAS and WGCNA approaches

Frontiers in Plant Science, 2023
IntroductionIsoflavones are the secondary metabolites synthesized by the phenylpropanoid biosynthesis pathway in soybean that benefits human and plant health.MethodsIn this study, we have profiled seed isoflavone content by HPLC in 1551 soybean ...
Muhammad Azam, Shengrui Zhang, Jing Li, Muhammad Ahsan, Kwadwo Gyapong Agyenim-Boateng, Jie Qi, Yue Feng, Yitian Liu, Bin Li, Lijuan Qiu, Junming Sun   +10 more
doaj   +1 more source

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source

Deriving GWAS summary estimates for paternal smoking in UK biobank: a GWAS by subtraction

BMC Research Notes, 2023
Objective To use genome-wide association study (GWAS) by subtraction, a method for deriving novel GWASs from existing summary statistics, to derive genome-wide summary statistics for paternal smoking.
Benjamin Woolf, Hannah M. Sallis, Marcus R. Munafò, Dipender Gill   +3 more
doaj   +1 more source