Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa [PDF]
, 2018 Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified.
Aguilera-McKay, F. +7 more
core +1 more source
Genomic factors underlying sex differences in trauma-related disorders
Neurobiology of Stress, 2021 Post-traumatic stress disorder (PTSD) is a devastating illness with treatment that is effective in only approximately half of the population. This limited rate of response highlights the necessity for research into underlying individual biological ...
Olga Y. Ponomareva, Kerry J. Ressler
doaj +1 more source
Elevated polygenic burden for autism is associated with differential DNA methylation at birth
Genome Medicine, 2018 Background Autism spectrum disorder (ASD) is a severe neurodevelopmental disorder characterized by deficits in social communication and restricted, repetitive behaviors, interests, or activities.
Eilis Hannon +22 more
doaj +1 more source
Syringohydromyelia in Dogs: The Genomic Component Underlying a Complex Neurological Disease
Animals, 2022 Syringohydromyelia (SHM) is a neurological disorder characterized by the appearance of fluid-containing cavities within the spinal cord. Although SHM is thought to be under multigenic control, the molecular basis of this disease remains poorly defined. A
Sandra Andrino +5 more
doaj +1 more source
The role of 39 psoriasis risk variants on age of psoriasis onset. [PDF]
, 2013 Recent genome-wide association studies (GWAS) have identified multiple genetic risk factors for psoriasis, but data on their association with age of onset have been marginally explored.
Butler, Daniel +12 more
core +2 more sources
Genome-wide association analysis to identify QTL for carcass traits in Hanwoo (Korean native cattle)
Indian Journal of Animal Sciences, 2019 A genome-wide association study (GWAS) was performed to investigate the genetic markers associated with carcass traits of Hanwoo (Bos taurus coreanae) steer in the Gangwon region of Korea.
MIN-WOOK HONG +7 more
doaj +1 more source
Uncovering Networks from Genome-Wide Association Studies via Circular Genomic Permutation [PDF]
, 2012 Genome-wide association studies (GWAS) aim to detect single nucleotide polymorphisms (SNP) associated with trait variation. However, due to the large number of tests, standard analysis techniques impose highly stringent significance thresholds, leaving ...
Cabrera, Claudia P +10 more
core +1 more source
Deriving GWAS summary estimates for paternal smoking in UK biobank: a GWAS by subtraction
BMC Research Notes, 2023 Objective To use genome-wide association study (GWAS) by subtraction, a method for deriving novel GWASs from existing summary statistics, to derive genome-wide summary statistics for paternal smoking.
Benjamin Woolf +3 more
doaj +1 more source
BMC Genomics, 2018 Background Umbilical hernia is one of the most prevalent congenital defect in pigs, causing economic losses and substantial animal welfare problems. Identification and implementation of genomic regions controlling umbilical hernia in breeding is of great
Eli Grindflek +3 more
doaj +1 more source
Genome-wide association study and subsequent functional analysis reveal regulatory mechanism underlying piglet diarrhea [PDF]
Animal BioscienceObjective Piglet diarrhea poses a serious threat to piglet health and the livestock economy, and is one of the most pressing problems in animal husbandry.
Dong Chen +9 more
doaj +1 more source