Characterising genome architectures using genome decomposition analysis [PDF]
BMC Genomics, 2021 AbstractGenome architecture describes how genes and other features are arranged in genomes. These arrangements reflect the evolutionary pressures on genomes and underlie biological processes such as chromosomal segregation and the regulation of gene expression.
Eerik Aunin +2 more
openaire +4 more sources
Microbial genomic taxonomy [PDF]
, 2013 A need for a genomic species definition is emerging from several independent studies worldwide. In this commentary paper, we discuss recent studies on the genomic taxonomy of diverse microbial groups and a unified species definition based on genomics ...
Chimetto, Luciane +5 more
core +3 more sources
Analysis of Archived Residual Newborn Screening Blood Spots After Whole Genome Amplification [PDF]
, 2015 Deidentified newborn screening bloodspot samples (NBS) represent a valuable potential resource for genomic research if impediments to whole exome sequencing of NBS deoxyribonucleic acid (DNA), including the small amount of genomic DNA in NBS material ...
Benstead-Hume, Graeme +7 more
core +3 more sources
ERβ and NFκB—Modulators of Zearalenone-Induced Oxidative Stress in Human Prostate Cancer Cells
Toxins, 2020 Nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) is commonly expressed in prostate cancer (PCa) cells and is associated with increased proliferation, metastases and androgen independence.
Karolina Kowalska +4 more
doaj +1 more source
Frontiers in Public Health, 2020 The population structure of human isolates of Listeria monocytogenes in Emilia-Romagna, Italy, from 2012 to 2018 was investigated with the aim of evaluating the presence of genomic clusters indicative of possible outbreaks, the proportion of cluster ...
Erika Scaltriti +6 more
doaj +1 more source
Automated Annotation-Based Bio-Ontology Alignment with Structural Validation [PDF]
, 2009 We outline the structure of an automated process to both align multiple bio-ontologies in terms of their genomic co-annotations, and then to measure the structural quality of that alignment.
Amanda White +9 more
core +2 more sources
Clinical Case Reports, 2019 Recognition of a de novo mutation in NR4A2 associated with a neurodevelopmental phenotype reinforces its role in 2q23q24 microdeletion syndrome. Using the proband WES data and the probability of loss‐of‐function intolerance index (pLi) set at 1.0 ...
Luiza L. P. Ramos +7 more
doaj +1 more source
Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients [PDF]
, 2017 Background: Human erythropoiesis is characterized by distinct gene expression profiles at various developmental stages. Previous studies suggest that fetal-to-adult hemoglobin switch is regulated by a complex mechanism, in which many key players still ...
Ali, Bassam R. +11 more
core +5 more sources
An investigation into inter- and intragenomic variations of graphic genomic signatures [PDF]
, 2015 We provide, on an extensive dataset and using several different distances, confirmation of the hypothesis that CGR patterns are preserved along a genomic DNA sequence, and are different for DNA sequences originating from genomes of different species ...
Karamichalis, Rallis +3 more
core +3 more sources
Removing batch effects for prediction problems with frozen surrogate variable analysis [PDF]
, 2013 Batch effects are responsible for the failure of promising genomic prognos- tic signatures, major ambiguities in published genomic results, and retractions of widely-publicized findings.
Bravo, Héctor Corrada +2 more
core +3 more sources