Results 41 to 50 of about 23,710,291 (301)

High contiguity Arabidopsis thaliana genome assembly with a single nanopore flow cell

open access: yesNature Communications, 2018
Long-read sequencing technologies facilitate efficient and high quality genome assembly. Here Michael et al. achieve a fast reference assembly for Arabidopsis thaliana KBS-Mac-74 accession using the handheld Oxford Nanopore MinION sequencer and consumer ...
Todd P. Michael   +8 more
doaj   +1 more source

Is There an Exercise-Intensity Threshold Capable of Avoiding the Leaky Gut?

open access: yesFrontiers in Nutrition, 2021
Endurance-sport athletes have a high incidence of gastrointestinal disorders, compromising performance and impacting overall health status. An increase in several proinflammatory cytokines and proteins (LPS, I-FABP, IL-6, IL-1β, TNF-α, IFN-γ, C-reactive ...
Filipe M. Ribeiro   +10 more
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain

open access: yesCell Reports, 2016
Organoids derived from human pluripotent stem cells recapitulate the early three-dimensional organization of the human brain, but whether they establish the epigenomic and transcriptional programs essential for brain development is unknown.
Chongyuan Luo   +5 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

A global network for investigating the genomic epidemiology of malaria.

open access: yes, 2008
Large-scale studies of genomic variation could assist efforts to eliminate malaria. But there are scientific, ethical and practical challenges to carrying out such studies in developing countries, where the burden of disease is greatest.
Malaria Genomic Epidemiology Network, Malaria Genomic Epidemiology
core   +1 more source

Accuracy of multi-trait genomic selection using different methods [PDF]

open access: yes, 2011
Background Genomic selection has become a very important tool in animal genetics and is rapidly emerging in plant genetics. It holds the promise to be particularly beneficial to select for traits that are difficult or expensive to measure, such as traits
Veerkamp Roel F   +5 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Selection and Characterization of Cell Line–Virus Pairs for Sensitive Viral Detection Assays in Biopharmaceutical Testing

open access: yesMethods and Protocols
Ensuring viral safety is a critical aspect of biopharmaceutical production, requiring sensitive and reliable methods for detecting adventitious agents. In this study, we systematically evaluated the performance of selected cell line–virus combinations to
Agnieszka Staniszewska   +1 more
doaj   +1 more source

A B-ARR-mediated cytokinin transcriptional network directs hormone cross-regulation and shoot development

open access: yesNature Communications, 2018
Cytokinin fulfills its diverse roles in planta through a series of transcriptional responses. We identify the in vivo DNA binding site profiles for three genetically redundant type-B ARABIDOPSIS RESPONSE REGULATORS (B-ARRs): ARR1, ARR10, and ARR12.
Mingtang Xie   +5 more
doaj   +1 more source

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