Results 11 to 20 of about 131,595 (265)

The Human Genome Epidemiology Network [PDF]

American Journal of Epidemiology, 1998
Progress on the Human Genome Project has led to an explosion of genetic information (1). Of the estimated 100,000 human genes, more than 9,000 have been discovered, and more than 5,000 have been mapped to specific chromosomes (2). There are approximately 500 genes for which there are genetic tests used in medical practice (3). Almost daily, discoveries
M J, Khoury, J S, Dorman
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Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance

Nature Communications, 2022
Understanding the emergence, evolution, and transmission of antibiotic resistance genes (ARGs) is essential to combat antimicrobial resistance. Here, Munk et al. analyse ARGs in hundreds of sewage samples from 101 countries and describe regional patterns,
Patrick Munk, Christian Brinch, Frederik Duus Møller, Thomas N. Petersen, Rene S. Hendriksen, Anne Mette Seyfarth, Jette S. Kjeldgaard, Christina Aaby Svendsen, Bram van Bunnik, Fanny Berglund, Global Sewage Surveillance Consortium, D. G. Joakim Larsson, Marion Koopmans, Mark Woolhouse, Frank M. Aarestrup   +14 more
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Metagenomics analysis of bacteriophages and antimicrobial resistance from global urban sewage

Scientific Reports, 2021
Bacteriophages, or phages, are ubiquitous bacterial and archaeal viruses with an estimated total global population of 1031. It is well-known that wherever there are bacteria, their phage counterparts will be found, aiding in shaping the bacterial ...
Josephine E. S. Strange, Pimlapas Leekitcharoenphon, Frederik Duus Møller, Frank M. Aarestrup   +3 more
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Human genome epidemiology, progress and future [PDF]

The Journal of Biomedical Research, 2013
Human genome epidemiology (HuGE) uses systematic applications of epidemiologic methods to assess the impact of human genetic variation on health and disease. In the past ten years, human genome epidemiology has made great progresses along with advances in genomics technologies, which make it possible for the examination of genetic variants in a large ...
Shen, Hongbing, Jin, Guangfu
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Genomic epidemiology and multilevel genome typing ofBordetella pertussis

Emerging Microbes & Infections, 2023
AbstractBordetella pertussisis responsible for the respiratory infectious disease pertussis (or whooping cough), which causes one of the most severe diseases in infants, although it can be prevented by whole cell and acellular vaccines. The recent resurgence of pertussis is partially due to pathogen adaptation to vaccines as well as resistance to ...
Michael Payne, Zheng Xu, Dalong Hu, Sandeep Kaur, Sophie Octavia, Vitali Sintchenko, Ruiting Lan   +6 more
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Global Distribution and Diversity of Prevalent Sewage Water Plasmidomes

mSystems, 2022
Sewage water from around the world contains an abundance of short plasmids, several of which harbor antimicrobial resistance genes (ARGs). The global dynamics of plasmid-derived antimicrobial resistance and functions are only starting to be unveiled ...
Frederik Teudt, Saria Otani, Frank M. Aarestrup   +2 more
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Genomic epidemiology of artemisinin resistant malaria [PDF]

eLife, 2016
The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelch13 mutations which cause resistance in Southeast Asia are present at low frequency in Africa.
Amato, R, Miotto, O, Woodrow, CJ, Almagro-Garcia, J, Sinha, I, Campino, S, Mead, D, Drury, E, Kekre, M, Sanders, M, Amambua-Ngwa, A, Amaratunga, C, Amenga-Etego, L, Andrianaranjaka, V, Apinjoh, T, Ashley, E, Auburn, S, Awandare, GA, Baraka, V, Barry, A, Boni, MF, Borrmann, S, Bousema, T, Branch, O, Bull, PC, Chotivanich, K, Conway, DJ, Craig, A, Day, NP, Djimde, A, Dolecek, C, Dondorp, AM, Drakeley, C, Duffy, P, Echeverry, DF, Egwang, TG, Fairhurst, RM, Faiz, MA, Fanello, CI, Tran, TH, Hodgson, A, Imwong, M, Ishengoma, D, Lim, P, Lon, C, Marfurt, J, Marsh, K, Mayxay, M, Michon, P, Mobegi, V, Mokuolu, OA, Montgomery, J, Mueller, I, Kyaw, MP, Newton, PN, Nosten, F, Noviyanti, R, Nzila, A, Ocholla, H, Oduro, A, Onyamboko, M, Ouedraogo, J-B, Phyo, APP, Plowe, C, Price, RN, Pukrittayakamee, S, Randrianarivelojosia, M, Ringwald, P, Ruiz, L, Saunders, D, Shayo, A, Siba, P, Takala-Harrison, S, Thanh, T-NN, Thathy, V, Verra, F, Wendler, J, White, NJ, Ye, H, Cornelius, VJ, Giacomantonio, R, Muddyman, D, Henrichs, C, Malangone, C, Jyothi, D, Pearson, RD, Rayner, JC, McVean, G, Rockett, KA, Miles, A, Vauterin, P, Jeffery, B, Manske, M, Stalker, J, Maclnnis, B, Kwiatkowski, DP   +95 more
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Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania

Nature Communications, 2019
Four genome-wide associated loci are currently known for malaria susceptibility. Here, the authors expand on earlier work by combining data from 11 malaria-endemic countries and additional population sequencing informing an African-enriched imputation ...
Malaria Genomic Epidemiology Network
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Modelling the effectiveness of surveillance based on metagenomics in detecting, monitoring, and forecasting antimicrobial resistance in livestock production under economic constraints

Scientific Reports, 2023
Current surveillance of antimicrobial resistance (AMR) is mostly based on testing indicator bacteria using minimum inhibitory concentration (MIC) panels. Metagenomics has the potential to identify all known antimicrobial resistant genes (ARGs) in complex
Ofosuhene O. Apenteng, Frank M. Aarestrup, Håkan Vigre   +2 more
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Salmonella Derby adaptation to swine and simultaneous attenuation for humans go through decay of Salmonella Pathogenicity Island I

Microbiology Spectrum, 2023
We report the identification, within the global population of Salmonella Derby, of a lineage highly diffused and expanding in swine while being significantly under-represented in humans which carries stop mutations in the Salmonella Pathogenicity Island ...
Melissa Berni, Luca Bolzoni, Ilaria Menozzi, Alessandra Dodi, Chiara Bracchi, Marina Morganti, Erika Scaltriti, Stefano Pongolini, Martina Tambassi   +8 more
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