Results 21 to 30 of about 305,884 (298)

A novel locus of resistance to severe malaria in a region of ancient balancing selection. [PDF]

open access: yes, 2015
The high prevalence of sickle haemoglobin in Africa shows that malaria has been a major force for human evolutionary selection, but surprisingly few other polymorphisms have been proven to confer resistance to malaria in large epidemiological studies. To
Band, G   +5 more
core   +1 more source

Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania

open access: yesNature Communications, 2019
Four genome-wide associated loci are currently known for malaria susceptibility. Here, the authors expand on earlier work by combining data from 11 malaria-endemic countries and additional population sequencing informing an African-enriched imputation ...
Malaria Genomic Epidemiology Network
doaj   +1 more source

Modelling the effectiveness of surveillance based on metagenomics in detecting, monitoring, and forecasting antimicrobial resistance in livestock production under economic constraints

open access: yesScientific Reports, 2023
Current surveillance of antimicrobial resistance (AMR) is mostly based on testing indicator bacteria using minimum inhibitory concentration (MIC) panels. Metagenomics has the potential to identify all known antimicrobial resistant genes (ARGs) in complex
Ofosuhene O. Apenteng   +2 more
doaj   +1 more source

Salmonella Derby adaptation to swine and simultaneous attenuation for humans go through decay of Salmonella Pathogenicity Island I

open access: yesMicrobiology Spectrum, 2023
We report the identification, within the global population of Salmonella Derby, of a lineage highly diffused and expanding in swine while being significantly under-represented in humans which carries stop mutations in the Salmonella Pathogenicity Island ...
Melissa Berni   +8 more
doaj   +1 more source

Characterizing <i>Staphylococcus aureus</i> genomic epidemiology with multilevel genome typing. [PDF]

open access: yesmSystems
ABSTRACT Staphylococcus aureus is a major source of both hospital- and community-acquired infections worldwide. Advances in whole-genome sequencing (WGS) technologies have recently generated large volumes of S. aureus
Payne M   +4 more
europepmc   +2 more sources

Status and potential of bacterial genomics for public health practice : a scoping review [PDF]

open access: yes, 2019
Background: Next-generation sequencing (NGS) is increasingly being translated into routine public health practice, affecting the surveillance and control of many pathogens.
Boon, Nele AM   +6 more
core   +2 more sources

Long-Term Temporal Stability of the Resistome in Sewage from Copenhagen

open access: yesmSystems, 2020
Antimicrobial resistance (AMR) is a major threat to global health, and it is crucial to understand the epidemiological aspects in order to predict the emergence and propagation of AMR genes.
Christian Brinch   +5 more
doaj   +1 more source

Standard Sample Storage Conditions Have an Impact on Inferred Microbiome Composition and Antimicrobial Resistance Patterns

open access: yesMicrobiology Spectrum, 2021
Storage of biological specimens is crucial in the life and medical sciences. Storage conditions for samples can be different for a number of reasons, and it is unclear what effect this can have on the inferred microbiome composition in metagenomics ...
Casper Sahl Poulsen   +3 more
doaj   +1 more source

The Infectious Disease Ontology in the Age of COVID-19 [PDF]

open access: yes, 2021
The Infectious Disease Ontology (IDO) is a suite of interoperable ontology modules that aims to provide coverage of all aspects of the infectious disease domain, including biomedical research, clinical care, and public health.
Babcock, Shane   +3 more
core   +1 more source

Epidemiologic and Genomic Reidentification of Yaws, Liberia [PDF]

open access: yesEmerging Infectious Diseases, 2021
We confirmed endemicity and autochthonous transmission of yaws in Liberia after a population-based, community-led burden estimation (56,825 participants). Serologically confirmed yaws was rare and focal at population level (24 cases; 2.6 [95% CI 1.4-3.9] cases/10,000 population) with similar clinical epidemiology to other endemic countries in West ...
Joseph W.S. Timothy   +11 more
openaire   +4 more sources

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