Results 121 to 130 of about 48,815 (295)

Estimating genomic breeding values from the QTL-MAS Workshop Data using a single SNP and haplotype/IBD approach

, 2009
Two models that estimated genomic estimated breeding values (EBVs) were applied: one used constructed haplotypes (based on alleles of 20 markers) and IBD matrices, another used single SNP regression.
Calus, M.P.L., Veerkamp, R.F., Roos, S., de   +2 more
core  

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Prediction of genomic breeding values for reproductive traits in Nellore heifers

, 2019
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Processo FAPESP: :2009/16118-5The objective of this study was to assess the accuracy of genomic predictions for female reproductive traits in Nellore cattle.
Tonhati, Humberto, Irano, Natalia [UNESP], Oliveira, Henrique Nunes de [UNESP], Albuquerque, Lucia Galva de [UNESP], Solar Diaz, Lara Del Pilar, Takada, Luciana, Baldi, Fernando [UNESP], Hermisdorff, Isis da Costa, Carvalheiro, Roberto [UNESP], Tonhati, Humberto [UNESP], Costa, Raphael Bermal, Baldi, Fernando, Albuquerque, Lucia Galva de, Costa, Raphael Bermal [UNESP], Takada, Luciana [UNESP], Oliveira, Henrique Nunes de, Solar Diaz, Lara Del Pilar [UNESP], Carvalheiro, Roberto, Irano, Natalia   +18 more
core   +1 more source

Genomic predictions for crossbred dairy cattle

, 2020
Genomic evaluations are useful for crossbred as well as purebred populations when selection is applied to commercial herds. Dairy farmers had already spent more than $1 million to genotype over 32,000 crossbred animals before US genomic evaluations ...
Haagen, I. W., VanRaden, P. M., Chud, T. C.S. [UNESP], Wiggans, G. R., Tooker, M. E., Megonigal, J. H., Norman, H. D.   +6 more
core   +1 more source

eQTL Meta‐Analysis Reveals Conserved and Population‐Specific Regulatory Variation Underlying Nutritional Trait Evolution and Domestication in Tomato

Advanced Science, EarlyView.
A comprehensive meta‐analysis of expression quantitative trait loci (eQTLs) across five diverse tomato populations reveals a high‐resolution atlas of transcriptional regulation and uncovers conserved and population‐specific regulatory architectures underlying fruit nutritional quality traits, including flavonoids, sugars, organic acids, carotenoids ...
Jiantao Zhao, Xin Wang, Jing Zhang, Ryan McQuinn, Je Min Lee, Itay Gonda, Ari Feder, Yimin Xu, Baike Wang, Qinghui Yu, Denise M. Tieman, Sanwen Huang, Harry Klee, James J. Giovannoni, Zhangjun Fei   +14 more
wiley   +1 more source

Relevance of test information in horse breeding

, 2011
The aims of this study were 1) to determine the role of test results of young horses in selection for sport performance, 2) to assess the genetic diversity of a closed horse breed and 3) the consequences of inbreeding for male reproduction.
Ducro, B.J.
core  

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Early Selection Enabled by the Implementation of Genomic Selection in Coffea arabica Breeding

Frontiers in Plant Science, 2019
Genomic Selection (GS) has allowed the maximization of genetic gains per unit time in several annual and perennial plant species. However, no GS studies have addressed Coffea arabica, the most economically important species of the genus Coffea. Therefore,
Tiago Vieira Sousa, Eveline Teixeira Caixeta, Emilly Ruas Alkimim, Antonio Carlos Baião Oliveira, Antonio Alves Pereira, Ney Sussumu Sakiyama, Laércio Zambolim, Marcos Deon Vilela Resende   +7 more
doaj   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source