Results 101 to 110 of about 184,862 (303)

Systematic analysis of genomic alterations in prostate cancer

, 2011
PhDProstate cancer is the most common male cancer in Western countries. The genetic mechanism underlying its initiation and progression is still unclear.
Mao, Xueying
core  

Parameter Identifiability and Redundancy in a General Class of Stochastic Carcinogenesis Models

, 2009
Background Heidenreich et al. (Risk Anal 1997 17 391–399) considered parameter identifiability in the context of the two-mutation cancer model and demonstrated that combinations of all but two of the model parameters are identifiable.
Wolfgang F Heidenreich, Little, Mark, Little Mark P., Li Guangquan, Li, G.Q., Heidenreich, W.F., Li, Guangquan, Heidenreich, Wolfgang, Mark P Little, Little, M.P., Heidenreich Wolfgang F., Guangquan Li   +11 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Advancing prognostic understanding in hepatocellular carcinoma through the integration of genomic instability and lncRNA signatures: GILncSig model

: The recently published study by Duan et al introduces a promising method that combines genomic instability and long non-coding RNAs to improve the prognostic evaluation of hepatocellular carcinoma (HCC), a deadly cancer associated with considerable ...
Zappavigna, Silvia, Caraglia, Michele, Francesca Pentimalli, Bocchetti, Marco, Scrima, Marianna, Marianna Scrima, Pentimalli, Francesca, Misso, Gabriella, Alessia Maria Cossu, Cossu, Alessia Maria, Gabriella Misso, Marco Bocchetti, Silvia Zappavigna, Michele Caraglia   +13 more
core   +1 more source

AUC-RF: A New Strategy for Genomic Profiling with Random Forest [PDF]

, 2011
Objective: Genomic profiling, the use of genetic variants at multiple loci simultaneously for the prediction of disease risk, requires the selection of a set of genetic variants that best predicts disease status.
Luz Calle, M., Nuria Malats, Urrea, Victor, Victor Urrea, Calle, M. Luz, Urrea Gales, Víctor, Anne-Laure Boulesteix, Boulesteix, Anne-Laure, Malats, Nuria, M. Luz Calle, Malats i Riera, Núria   +10 more
core   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

HBx targets centrosomal protein TAX1BP2 to promote genomic instability

, 2015
Centrosome is a major microtubule-organizing centre for regulating spindle assembly and bipolarity.Evidence suggests that cancer is a multi-step accumulation process of genomic instability resulted from centrosome dysfunction.
Tang, HC, Li, SK, Lau, PY, Zhou, Y, Ching, YP   +4 more
core  

A novel ATM-dependent checkpoint defect distinct from loss of function mutation promotes genomic instability in melanoma

, 2016
Melanomas have high levels of genomic instability that can contribute to poor disease prognosis. Here, we report a novel defect of the ATM-dependent cell cycle checkpoint in melanoma cell lines that promotes genomic instability.
Dahmer-Heath, M., Pavey, S., Pavey, Sandra, Burmeister, B., Gabrielli, Brian, Ellis, Jonathan J., Chia, KeeMing, Skalamera, Dubravka, Brooks, K., Škalamera, D., Burmeister, Bryan, Ellis, Jonathan J, Brooks, Kelly, Grossman, G., Grossman, Gavriel, Spoerri, L., Spoerri, Loredana, Chia, K., Ellis, J. J., Gabrielli, B., Dahmer-Heath, Mareike   +20 more
core   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Emerging concepts in drug discovery for cancer therapy

Molecular Oncology, 2022
Matilde Murga, Oscar Fernandez‐Capetillo   +1 more
doaj   +1 more source