Results 91 to 100 of about 184,862 (303)

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis

Cell Death and Disease
SETD8 is a methyltransferase that is overexpressed in several cancers, which monomethylates H4K20 as well as other non-histone targets such as PCNA or p53.
Matilde Murga, Gema Lopez-Pernas, Robert Soliva, Elena Fueyo-Marcos, Corina Amor, Ignacio Faustino, Marina Serna, Alicia G. Serrano, Lucía Díaz, Sonia Martínez, Carmen Blanco-Aparicio, Marta Elena Antón, Brinton Seashore-Ludlow, Joaquín Pastor, Rozbeh Jafari, Miguel Lafarga, Oscar Llorca, Modesto Orozco, Oscar Fernández-Capetillo   +18 more
doaj   +1 more source

Role of microRNAs and DNA methyltransferases in transmitting induced genomic instability between cell generations

Frontiers in Public Health, 2014
There is limited understanding of how radiation or chemicals induce genomic instability, and how the instability is epigenetically transmitted to the progeny of exposed cells or organisms.
Katriina eHuumonen, Merja eKorkalainen, Matti eViluksela, Matti eViluksela, Tapani eLahtinen, Jonne eNaarala, Jukka eJuutilainen   +6 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Hydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis

, 2008
Claire M Payne, Carol Bernstein, Katerina Dvorak, Harris BernsteinDepartment of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, Arizona, USAAbstract: Sporadic colon cancer is caused predominantly by dietary factors.
Harris Bernstein, Katerina Dvorak, Claire M Payne, Carol Bernstein   +3 more
core  

The role of Ephexin1 in translation and mTOR-targeted cancer therapy

Experimental and Molecular Medicine
Ephexin1, also known as neuronal guanine nucleotide exchange factor (NGEF), plays a key role in axon guidance and synaptic homeostasis. However, our recent studies have revealed a critical role for Ephexin1 in the pathogenesis of colon and lung cancers ...
Jeeho Kim, In-Youb Chang, Jung-Hee Lee, Jeongsik Yong, Young Jin Jeon, Ho Jin You   +5 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Aneuploidy Drives Genomic Instability in Yeast [PDF]

, 2011
Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative capacity. To investigate one mechanism by which aneuploidy could contribute to tumorigenesis, we examined the effects of aneuploidy on ...
Humpton, T. J., Sheltzer, J. M., Blank, Heidi Marie, Hiraoka, Yasushi, Hiraoka, Y., Sarah J. Pfau, Humpton, Timothy J., Brito, Ilana Lauren, Tange, Y., Niwa, O., Heidi M. Blank, Ilana L. Brito, Timothy J. Humpton, George, B. M., George, Benson M., Benson M. George, Amon, A., Pfau, Sarah Jeanne, Niwa, Osami, Sheltzer, Jason Meyer, Blank, H. M., Tange, Yoshie, Brito, I. L., Amon, Angelika B, Yoshie Tange, Yasushi Hiraoka, Jason M. Sheltzer, Osami Niwa, Angelika Amon, Pfau, S. J.   +29 more
core   +1 more source

Nuclear TRADD prevents DNA damage-mediated death by facilitating non-homologous end-joining repair

Scientific Reports, 2017
TNF receptor-associated death domain (TRADD) is an essential mediator of TNF receptor signaling, and serves as an adaptor to recruit other effectors. TRADD has been shown to cycle between the cytoplasm and nucleus due to its nuclear localization (NLS ...
Gi-Bang Koo, Jae-Hoon Ji, Hyeseong Cho, Michael J. Morgan, You-Sun Kim   +4 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source