Results 191 to 200 of about 1,069,336 (306)

Genome-wide association study identifies consistent genomic loci for yield and nutritional quality in Ethiopian sorghum landraces. [PDF]

Plant Genome
Endalamaw C, Menamo TM, Kebede FG, Wondimu Z, Tekle HT, Shamuyarira K, Jacoby A, Labuschagne MT.   +7 more
europepmc   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

ALIGaToR: a tool for the automated annotation of immunoglobulin and T cell receptor genomic loci. [PDF]

Oxf Open Immunol
Schramm CA, Olubo S, Douek DC.
europepmc   +1 more source

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

CUT&Tag overcomes biases of ChIP and establishes chromatin patterns for repetitive genomic loci. [PDF]

iScience
Park BJ, Hua S, Casler KD, Cefaloni E, Ayers MC, Lake RF, Murphy KE, Vertino PM, O'Connell MR, Murphy PJ.   +9 more
europepmc   +1 more source

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

The Baladi cattle are a genetic sieve for indicine and African-taurine genomic loci with positive effects on adaptation to harsh Mediterranean environments. [PDF]

BMC Genomics
Shabtay A, Soller M, Sölkner J, Mészáros G, Sonstegard T, Ünal EO, Huson HJ, Utsunomiya Y, Agmon R, Cohen-Zinder M, Bagnato A, Ferrari C, Strillacci MG, Lipkin E.   +13 more
europepmc   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection. [PDF]

Cell Rep
Shaw S, Li X, Buenconsejo GY, Zhou TH, Cohen A, Yasur-Landau D, Xiao R, Beiting DP, Anderson TJC, Striepen B.   +9 more
europepmc   +1 more source

Imaging of genomic loci in Trypanosoma brucei using an optimised LacO-LacI system. [PDF]

Mol Biochem Parasitol, 2023
Budzak J, Goodwin I, Tiengwe C, Rudenko G.   +3 more
europepmc   +1 more source