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Predicting immunotherapy response through genomics
Current Opinion in Genetics & Development, 2021Immune checkpoint inhibitors (ICI) aim to restore the immune system anti-tumor function by blocking two inhibitory axes: CTLA-4/CD28 and PD1/PDL1. ICI is established as a treatment option for multiple cancers, but their remarkable clinical impact is observed only in a fraction of patients.
Marina Candido Visontai, Cormedi +2 more
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2020
Genomic prediction is transforming animal and plant breeding and its utility to predict human disease risk is being explored. The method aims to predict an individual’s future phenotype based on only a DNA test. This lecture will introduce genomic prediction, including the basic concepts, main statistical models, validation strategies, and method ...
Fazel Almasi, Daetwyler, Hans, Zibei Lin
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Genomic prediction is transforming animal and plant breeding and its utility to predict human disease risk is being explored. The method aims to predict an individual’s future phenotype based on only a DNA test. This lecture will introduce genomic prediction, including the basic concepts, main statistical models, validation strategies, and method ...
Fazel Almasi, Daetwyler, Hans, Zibei Lin
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Microbiome genomics for cancer prediction
Nature Cancer, 2020Although cancer genomics is a powerful tool to understand cancer and develop diagnostic tools, the contribution of the microbiome in cancer diagnosis and clinical assessment is much less studied. Elinav, Greten and colleagues provide their respective views on how studying cancer metagenomes could facilitate identification, diagnosis and staging of ...
Adlung, Lorenz +3 more
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2010
Advances in the biological characterization of tumors has led to the design and development of anticancer agents targeting specific molecular alterations. The majority of these agents are designed to silence phosphorylation signals that are required for the development and maintenance of the cancer phenotype in specific tumor types.
Rakesh, Kumar, Rafael G, Amado
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Advances in the biological characterization of tumors has led to the design and development of anticancer agents targeting specific molecular alterations. The majority of these agents are designed to silence phosphorylation signals that are required for the development and maintenance of the cancer phenotype in specific tumor types.
Rakesh, Kumar, Rafael G, Amado
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SIFT missense predictions for genomes
Nature Protocols, 2015The SIFT (sorting intolerant from tolerant) algorithm helps bridge the gap between mutations and phenotypic variations by predicting whether an amino acid substitution is deleterious. SIFT has been used in disease, mutation and genetic studies, and a protocol for its use has been previously published with Nature Protocols.
Robert Vaser +4 more
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Fold Predictions for Bacterial Genomes
Journal of Structural Biology, 2001Fold assignments for newly sequenced genomes belong to the most important and interesting applications of the booming field of protein structure prediction. We present a brief survey and a discussion of such assignments completed to date, using as an example several fold assignment projects for proteins from the Escherichia coli genome.
K, Pawlowski +3 more
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Evaluation of Predictive Genomic Applications
2020The last fifteen years have seen the emergence of Public Health Genomics (PHG), a multidisciplinary field related to the effective and responsible translation of genome-based knowledge and technologies to improve population health. While at the beginning the main concern of PHG was that genetic/genomic applications should be evaluated rigorously before
Villari P. +3 more
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Predicting disease using genomics
Nature, 2004Information from the human genome sequence will eventually alter many aspects of clinical practice. It will increase through our understanding of disease mechanisms, and guide the development of new drugs and therapeutic procedures. In the short term, however, knowledge of the genome will have a profound clinical impact on the diagnostic capability of ...
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Predicting structures for genome proteins
Current Opinion in Structural Biology, 1999Assigning three-dimensional protein folds to genome sequences is essential to understanding protein function. Although experimental three-dimensional structures are currently available for only a very small fraction of these sequences, computational fold assignment is able to assign folds to 20-30% of the sequences in various genomes.
D, Fischer, D, Eisenberg
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Exon prediction in eucaryotic genomes
Biochimie, 1996Two independent computer systems, NetPlantGene and AMELIE, dedicated to the identification of splice sites in plant and human genomes, respectively, are introduced here. Both methods were designed in relation to experimental work; they rely on automatically generated rules involving the nucleotide content of sequences regardless of the coding ...
Vignal, L. +6 more
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