Results 111 to 120 of about 4,045,535 (372)

The impact of epistatic selection on the genomic traces of selection [PDF]

Molecular Ecology, 2009
The rapid accumulation of genomic data has led to an explosion of studies searching for signals of past selection left within DNA sequences. Yet the majority of theoretical studies investigating the traces of selection have assumed a simple form of selection, without interactions among selectively fixed sites.
Sarah P, Otto, Michael C, Whitlock
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

New cycle, same old mistakes? Overlapping vs. discrete generations in long-term recurrent selection

BMC Genomics, 2022
Background Recurrent selection is a foundational breeding method for quantitative trait improvement. It typically features rapid breeding cycles that can lead to high rates of genetic gain.
Marlee R. Labroo, Jessica E. Rutkoski
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Adaptive estimation for Hawkes processes; application to genome analysis [PDF]

, 2010
The aim of this paper is to provide a new method for the detection of either favored or avoided distances between genomic events along DNA sequences. These events are modeled by a Hawkes process.
Reynaud-Bouret, Patricia, Schbath, Sophie   +1 more
core   +6 more sources

Genomic Selection in Horse Breeding

АГРОЗНАЊЕ, 2019
The aim of this paper was to present the general aspects of genomic selection in horse breeding and also to provide an overview of existing applications in horses breeding, with particular emphasis on the challenges of implementation and long-term use.
Gregić, Maja, Dokić, D., Bobić, Tina, Gantner, Vesna   +3 more
openaire   +6 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Weighted GBLUP in Simulated Beef Cattle Populations: Impact of Reference Population, Marker Density, and Heritability

Animals
Genomic selection (GS) is a technique that integrates genomic data, pedigree information, and individual phenotypes to enhance genetic improvements of economically important traits in livestock. While it has shown significant effects in dairy cattle, its
Le Zhou, Lin Zhu, Chencheng Chang, Fengying Ma, Zaixia Liu, Mingjuan Gu, Risu Na, Wenguang Zhang   +7 more
doaj   +1 more source

Genomic Selection and Use of Molecular Tools in Breeding Programs for Indigenous and Crossbred Cattle in Developing Countries: Current Status and Future Prospects

Frontiers in Genetics, 2019
Genomic selection (GS) has resulted in rapid rates of genetic gains especially in dairy cattle in developed countries resulting in a higher proportion of genomically proven young bulls being used in breeding.
R. Mrode, J. Ojango, A. M. Okeyo, J. Mwacharo   +3 more
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source