Results 131 to 140 of about 2,697,056 (259)
Frontiers in Genetics, 2019 Within aquaculture industries, selection based on genomic information (genomic selection) has the profound potential to change genetic improvement programs and production systems. Genomic selection exploits the use of realized genomic relationships among
Kyall R. Zenger +11 more
doaj +1 more source
Other title: Title from HTML header (viewed Nov. 9, 2011): Judicial Selection Commission
, 2014 Updated irregularly; Began in 2002?; Title from main search screen (publisher's Web site, viewed Nov. 9, 2011).; At head of title: State of Connecticut.; Harvested from the web on 5/1/14Official website of the Connecticut Judicial Selection Commission ...
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
A Unified Comparative Evaluation of Genomic Prediction Models Across Four Aquaculture Species
FishesGenomic prediction has been increasingly applied in aquaculture selective breeding; however, systematic evaluations of prediction accuracy across multiple aquaculture species and analytical methods under a unified and comparable framework remain limited.
Jinxin Zhang +5 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Nonlinear genomic selection index accelerates multi-trait crop improvement
Nature CommunicationsLinear phenotypic and genomic selection indices assume additivity and linearity, limiting their ability to exploit nonlinear trait relationships. Here, we introduce the Quadratic Genomic Selection Index (QGSI), a genomic extension of the quadratic ...
J. Jesús Cerón-Rojas +7 more
doaj +1 more source
Other title: Title from HTML header (viewed Nov. 9, 2011): Judicial Selection Commission
, 2016 Updated irregularly; Began in 2002?; Title from main search screen (publisher's Web site, viewed Nov. 9, 2011).; At head of title: State of Connecticut.; Harvested from the web on 4/18/16Official website of the Connecticut Judicial Selection Commission ...
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
A low-coverage skim-sequencing and imputation pipeline for genomic selection
Genomic selection (GS) can accelerate plant breeding gains by reducing breeding cycle times, reducing phenotyping costs, or improving selection accuracy.
Sthapit, Sajal +6 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source