Results 131 to 140 of about 616,505 (302)

griffinp/desiccation-selection: Code for 'Genomic Trajectories to Desiccation Resistance' [PDF]

, 2016
<p>This set of non-production-ready scripts covers the downstream genomic data analysis described in the manuscript 'Genomic Trajectories to Desiccation Resistance: Convergence and Divergence in Genomic Responses among Replicate Selected Drosophila
griffinp
core   +1 more source

Genomic selection in maritime pine

Plant Science, 2016
A two-generation maritime pine (Pinus pinaster Ait.) breeding population (n=661) was genotyped using 2500 SNP markers. The extent of linkage disequilibrium and utility of genomic selection for growth and stem straightness improvement were investigated. The overall intra-chromosomal linkage disequilibrium was r(2)=0.01.
Isik, Fikret, Bartholomé, Jérôme, Farjat, Alfredo, Chancerel, Emilie, Raffin, Annie, Sanchez, Léopoldo, Plomion, Christophe, Bouffier, Laurent   +7 more
openaire   +4 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Selection Does Not Operate Primarily on Genes [PDF]

, 2008
This chapter offers a review of standard views about the requirements for natural selection to shape evolution and for the sorts of ‘units’ on which selection might operate.
Burian, Richard
core  

Introgression of a major QTL from an inferior into a superior population using genomic selection

Genetics Selection Evolution, 2009
Background Selection schemes aiming at introgressing genetic material from a donor into a recipient line may be performed by backcross-breeding programs combined with selection to preserve the favourable characteristics of the donor population.
Yazdi M Hossein, Sonesson Anna K, Ødegård Jørgen, Meuwissen Theo HE   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Linear Genomic Selection Indices [PDF]

, 2018
The linear genomic selection index (LGSI) is a linear combination of genomic estimated breeding values (GEBVs) used to predict the individual net genetic merit and select individual candidates from a nonphenotyped testing population as parents of the ...
Crossa, J., J. Jesus Céron-Rojas, Cerón-Rojas, J.J., José Crossa   +3 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Complete genome sequence of Rhizobium leguminosarum bv. trifolii strain WSM1325, an effective microsymbiont of annual Mediterranean clovers [PDF]

, 2010
Rhizobium leguminosarum bv trifolii is a soil-inhabiting bacterium that has the capacity to be an effective nitrogen fixing microsymbiont of a diverse range of annual Trifolium (clover) species.
Alex Copeland, John Howieson, Mavromatis, K, Cliff Han, Nolan, M, Victor Markowitz, Nandasena, K.G., Konstantinos Mavromatis, Ovchinikova, G, Lambert Bräu, Natalia Ivanova, Ardley, J.K., Wayne Reeve, Ardley, J, Patrick Chain, Bräu, L, Melino, V, Denton, M., Chain, P., Nandesena, K, Yates, R, Copeland, A., Melino, V., Ivanova, N, Ravi Tiwari, Ivanova, N., Graham O’Hara, Nandesena, K., O'Hara, G, Yates, R.J., Yates, R., Julie Ardley, Brettin, T., Kyrpides, N., Copeland, A, et al., Markowitz, V., Vanessa Melino, Reeve, W.G., O'Hara, G.W., Nolan, M., Miriam Land, Han, Cliff, Matthew Denton, Tiwari, R., Nikos Kyrpides, Matt Nolan, Thomas Brettin, Tiwari, R, Reeve, W., Han, C, Han, C., Reeve, W, Land, M., O'Hara, G., Ron Yates, Denton, M, Kemanthi Nandesena, Howieson, J, Mavromatis, K., Ardley, J., Galina Ovchinikova, Chain, P, Kyrpides, N, Ovchinikova, G., Land, M, Brettin, T, Howieson, J., Markowitz, V, Bräu, L.   +69 more
core   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source