Results 111 to 120 of about 984,187 (300)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Genome-wide profiling of human cap-independent translation-enhancing elements. [PDF]
, 2013 We report an in vitro selection strategy to identify RNA sequences that mediate cap-independent initiation of translation. This method entails mRNA display of trillions of genomic fragments, selection for initiation of translation and high-throughput ...
Briones, Natalia +10 more
core
Adaptive estimation for Hawkes processes; application to genome analysis [PDF]
, 2010 The aim of this paper is to provide a new method for the detection of either favored or avoided distances between genomic events along DNA sequences. These events are modeled by a Hawkes process.
Reynaud-Bouret, Patricia +1 more
core +6 more sources
Evolutionary genomics and the reach of selection [PDF]
Journal of Biology, 2009 Unexpected findings in evolutionary genomics both question the role of selection in genome evolution and clarify how genomes work.
openaire +3 more sources
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Genetics Selection Evolution, 2012 Background Over the last ten years, genomic selection has developed enormously. Simulations and results on real data suggest that breeding values can be predicted with high accuracy using genetic markers alone.
Van Grevenhof Elizabeth M +2 more
doaj +1 more source
Cytoscape: the network visualization tool for GenomeSpace workflows. [PDF]
, 2014 Modern genomic analysis often requires workflows incorporating multiple best-of-breed tools. GenomeSpace is a web-based visual workbench that combines a selection of these tools with mechanisms that create data flows between them.
Demchak, Barry +6 more
core +4 more sources
Genomic Selection in Horse Breeding
АГРОЗНАЊЕ, 2019 The aim of this paper was to present the general aspects of genomic selection in horse breeding and also to provide an overview of existing applications in horses breeding, with particular emphasis on the challenges of implementation and long-term use.
Gregić, Maja +3 more
openaire +5 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
SWEEPFINDER2: Increased sensitivity, robustness, and flexibility
, 2015 SweepFinder is a popular program that implements a powerful likelihood-based method for detecting recent positive selection, or selective sweeps. Here, we present SweepFinder2, an extension of SweepFinder with increased sensitivity and robustness to the ...
DeGiorgio, Michael +4 more
core +1 more source