Results 101 to 110 of about 2,697,056 (259)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Breeding for sustainable milk production [PDF]

, 2013
The overall aim of the research reported in this thesis was to investigate ways to mitigate deterioration in functional traits and reduce the environmental impact of milk production.
Hansen Axelsson, Helen
core   +1 more source

Genomic Selection in Horse Breeding

АГРОЗНАЊЕ, 2019
The aim of this paper was to present the general aspects of genomic selection in horse breeding and also to provide an overview of existing applications in horses breeding, with particular emphasis on the challenges of implementation and long-term use.
Gregić, Maja, Dokić, D., Bobić, Tina, Gantner, Vesna   +3 more
openaire   +5 more sources

Implementation of rapid cycle recurrent genomic selection for forage yield in perennial ryegrass

Opportunities exist to accelerate genetic gain in forage breeding using genome-wide selection approaches. In this study, we evaluated rapid cycle recurrent genomic selection (GS) as a means of improving genetic gain for value of annual forage yield.
A. Konkolewska, P. Conaghan, S. Byrne, D. Milbourne, S.K. Arojju   +4 more
core   +1 more source

Complementarity‐based selection strategy for genomic selection [PDF]

, 2020
Genomic selection is a technique that breeders use to select plant or animal individuals to mate and produce new generations of species. The conventional selection method is to select individuals that are either observed or predicted to be the best based
Moeinizade, Saba, Guiping Hu, Saba Moeinizade, Hu, Guiping, Wellner, Megan, Megan Wellner, Lizhi Wang, Wang, Lizhi   +7 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Response to genomic selection: The Bulmer effect and the potential of genomic selection when the number of phenotypic records is limiting

Genetics Selection Evolution, 2012
Background Over the last ten years, genomic selection has developed enormously. Simulations and results on real data suggest that breeding values can be predicted with high accuracy using genetic markers alone.
Van Grevenhof Elizabeth M, Van Arendonk Johan AM, Bijma Piter   +2 more
doaj   +1 more source

Haplotype applications in genomic selection

Genome Biology
There is an urgent need to increase sustainable crop production. The application of molecular marker technologies such as genomic selection and machine learning based approaches are aiding accelerated crop improvement. Conventional molecular marker technologies use single nucleotide polymorphisms to predict traits, however these do not capture local ...
MacNish, Tessa R., Bergmann, Thomas, Edwards, David   +2 more
openaire   +3 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Other title: Title from HTML header (viewed Nov. 9, 2011): Judicial Selection Commission

, 2011
Updated irregularly; Began in 2002?; Title from main search screen (publisher's Web site, viewed Nov. 9, 2011).; At head of title: State of Connecticut.; Harvested from the web on 11/10/11Official website of the Connecticut Judicial Selection Commission.

core   +1 more source