Results 101 to 110 of about 616,505 (302)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Genomic Selective Constraints in Murid Noncoding DNA [PDF]
, 2006 Recent work has suggested that there are many more selectively constrained, functional noncoding than coding sites in mammalian genomes. However, little is known about how selective constraint varies amongst different classes of noncoding DNA.
Peter D Keightley +5 more
core +1 more source
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source
GENOMIC SELECTION IN DAIRY CATTLE [PDF]
, 2023 Genomska selekcija je postala rutinska metoda pri mlečnih pasmah govedi. Z uvedbo genomske selekcije generacijski interval vsaj prepolovimo, kljub manjši točnosti plemenskih vrednosti, se genetski napredek poveča.
Marhat, Dejan
core
New cycle, same old mistakes? Overlapping vs. discrete generations in long-term recurrent selection
BMC Genomics, 2022 Background Recurrent selection is a foundational breeding method for quantitative trait improvement. It typically features rapid breeding cycles that can lead to high rates of genetic gain.
Marlee R. Labroo, Jessica E. Rutkoski
doaj +1 more source
Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach
FEBS Letters, EarlyView.The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring +3 more
wiley +1 more source
Genomic index selection provides a pragmatic framework for setting and refining multi-objective breeding targets in Miscanthus [PDF]
, 2018 Background: Miscanthus has potential as a biomass crop but the development of varieties that are consistently superior to the natural hybrid M. times giganteus has been challenging, presumably because of strong G timesE interactions and poor knowledge of
Bosch, M. +5 more
core +1 more source
AnimalsGenomic selection (GS) is a technique that integrates genomic data, pedigree information, and individual phenotypes to enhance genetic improvements of economically important traits in livestock. While it has shown significant effects in dairy cattle, its
Le Zhou +7 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Paternally expressed imprinted genes under positive Darwinian selection in Arabidopsis thaliana [PDF]
, 2019 Genomic imprinting is an epigenetic phenomenon where autosomal genes display uniparental expression depending on whether they are maternally or paternally inherited.
McKeown, Peter C. +15 more
core +2 more sources