Results 101 to 110 of about 984,187 (300)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Diversity, genetic mapping, and signatures of domestication in the carrot (Daucus carota L.) genome, as revealed by Diversity Arrays Technology (DArT) markers [PDF]

, 2013
Carrot is one of the most economically important vegetables worldwide, but genetic and genomic resources supporting carrot breeding remain limited. We developed a Diversity Arrays Technology (DArT) platform for wild and cultivated carrot and used it to ...
Allender, Charlotte J., Baranski, Rafal, Cavagnaro, Pablo, Ellison, Shelby, Grzebelus, Dariusz, Heller-Uszynska, Kasia, Iorizzo, Massimo, Kilian, Andrzej, Macko-Podgorni, Alicja, Nothnagel, Thomas, Senalik, Douglas, Simon, P. W. (Philipp W.)   +11 more
core   +3 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1643-1660, June 2026.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

The genetic architecture underlying the evolution of a rare piscivorous life history form in brown trout after secondary contact and strong introgression [PDF]

, 2018
Identifying the genetic basis underlying phenotypic divergence and reproductive isolation is a longstanding problem in evolutionary biology. Genetic signals of adaptation and reproductive isolation are often confounded by a wide range of factors, such as
Adams, Colin E., Elmer, Kathryn R., Hughes, Martin R., Jacobs, Arne, Robinson, Paige C.   +4 more
core   +2 more sources

GplusE: beyond genomic selection

Food and Energy Security, 2015
AbstractGplusE is a strategy for genomic selection in which the accuracy of assessment in the reference population for a primary trait such as yield is increased by the incorporation of data from high‐ throughput field phenotyping platforms. This increase in precision comes from both exploiting genetic relationships between traits and reducing the ...
Mackay, I, Ober, E, Hickey, John
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Optimising desired gain indices to maximise selection response

Frontiers in Plant Science
IntroductionIn plant breeding, we often aim to improve multiple traits at once. However, without knowing the economic value of each trait, it is hard to decide which traits to focus on.
Reem Joukhadar, Yongjun Li, Rebecca Thistlethwaite, Kerrie L. Forrest, Josquin F. Tibbits, Richard Trethowan, Richard Trethowan, Matthew J. Hayden, Matthew J. Hayden   +8 more
doaj   +1 more source

How to infer relative fitness from a sample of genomic sequences

, 2013
Mounting evidence suggests that natural populations can harbor extensive fitness diversity with numerous genomic loci under selection. It is also known that genealogical trees for populations under selection are quantifiably different from those expected
Dayarian, Adel, Shraiman, Boris I
core   +1 more source

Pitfalls and Remedies for Cross Validation with Multi-trait Genomic Prediction Methods. [PDF]

, 2019
Incorporating measurements on correlated traits into genomic prediction models can increase prediction accuracy and selection gain. However, multi-trait genomic prediction models are complex and prone to overfitting which may result in a loss of ...
Cheng, Hao, Runcie, Daniel
core   +1 more source

Phenomic Selection: A New and Efficient Alternative to Genomic Selection

, 2022
AbstractRecently, it has been proposed to switch molecular markers to near-infrared (NIR) spectra for inferring relationships between individuals and further performing phenomic selection (PS), analogous to genomic selection (GS). The PS concept is similar to genomic-like omics-based (GLOB) selection, in which molecular markers are replaced by ...
Robert, Pauline, Brault, Charlotte, Rincent, Renaud, Segura, Vincent   +3 more
openaire   +4 more sources