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MPAgenomics : An R package for multi-patients analysis of genomic markers [PDF]
, 2014 MPAgenomics, standing for multi-patients analysis (MPA) of genomic markers, is an R-package devoted to: (i) efficient segmentation, and (ii) genomic marker selection from multi-patient copy number and SNP data profiles. It provides wrappers from commonly
Blanck, Samuel +5 more
core +6 more sources
Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Aquaculture ReportsGlobal warming poses a significant challenge to aquaculture, with increasing water temperatures adversely affecting the growth, reproduction, and survival of aquatic species.
H.M.V. Udayantha +10 more
doaj +1 more source
Genomic selection on cacao for disease resistance : S04T08 [PDF]
, 2013 Under favorable conditions, diseases can cause losses up to 100% in cacao. Breeding has been the most effective strategy in reducing these losses. However, breeding is limited by the: a) long generation time; b) large tree size (9 m2/tree); c) multiple ...
Clément, Didier +6 more
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The asexual genome of Drosophila
, 2017 The rate of recombination affects the mode of molecular evolution. In high-recombining sequence, the targets of selection are individual genetic loci; under low recombination, selection collectively acts on large, genetically linked genomic segments ...
Lässig, Michael +2 more
core +1 more source
Selection Mapping Identifies Loci Underpinning Autumn Dormancy in Alfalfa (Medicago sativa). [PDF]
, 2018 Autumn dormancy in alfalfa (Medicago sativa) is associated with agronomically important traits including regrowth rate, maturity, and winter survival. Historical recurrent selection experiments have been able to manipulate the dormancy response.
Brummer, E Charles +3 more
core +3 more sources
Genomic selection in livestock populations
Genetics Research, 2010 SummaryMost traits of economic importance in livestock are either quantitative or complex. Despite considerable efforts, there has been only limited success in identifying the polymorphisms that cause variation in these traits. Nevertheless, selection based on estimated breeding values (BVs), calculated from data on phenotypic performance and pedigree ...
Goddard, Michael E. +2 more
openaire +5 more sources
Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Controlling the Overfitting of Heritability in Genomic Selection through Cross Validation. [PDF]
, 2017 In genomic selection (GS), all the markers across the entire genome are used to conduct marker-assisted selection such that each quantitative trait locus of complex trait is in linkage disequilibrium with at least one marker.
Jia, Zhenyu
core +2 more sources