Results 81 to 90 of about 2,697,056 (259)

Future trends in Animal Breeding due to new genetic tecnologies [PDF]

, 2011
The Darwin theory of evolution by natural selection is based on three principles: (a) variation; (b) inheritance; and (c) natural selection. Here, I take these principles as an excuse to review some topics related to the future research prospects in ...
Toro Ibañez, Miguel Angel
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Uninformative polymorphisms bias genome scans for signatures of selection [PDF]

, 2012
With the establishment of high-throughput sequencing technologies and new methods for rapid and extensive single nucleotide (SNP) discovery, marker-based genome scans in search of signatures of divergent selection between populations occupying ...
Daniel Berner, Roesti Marius, Berner Daniel, Marius Roesti, Salzburger Walter, Walter Salzburger, Salzburger, Walter, Berner, Daniel, Roesti, Marius   +8 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Comparative Transcriptome Analysis of White and Orange Skin of Clownfish Identifying Differentially Expressed Genes (DEGs) Underlying Pigment Expression

Fishes
Although the clownfish, Amphiprion ocellaris (A. ocellaris), is a popular ornamental marine fish worldwide, the mechanisms underlying color pattern variation remain unclear. Given that the Platinum-type clownfish, nearly entirely white, has high economic
Heegun Lee, Taehyug Jeong, Yeongkuk Kim, Sumi Jung, Jiyong Choi, Min-min Jung, Seunghwan Ko, Hayeong Oh, Juhyeok Kim, Jehee Lee, Seung Hwan Lee   +10 more
doaj   +1 more source

Optimising the analysis of transcript data using high density oligonucleotide arrays and genomic DNA-based probe selection [PDF]

, 2007
Background: Affymetrix GeneChip arrays are widely used for transcriptomic studies in a diverse range of species. Each gene is represented on a GeneChip array by a probe-set, consisting of up to 16 probe-pairs. Signal intensities across probe-pairs within
Sean T May, Martin R Broadley, John P Hammond, Graham Neil S, Neil S Graham, Philip J White, Broadley Martin R, Graham, Neil S., White, Philip J., Hammond John P, White Philip J, May Sean T, Broadley, Martin R., Hammond, John P., May, Sean T.   +14 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Identification of superior parental lines for biparental crossing via genomic prediction.

PLoS ONE, 2020
A parental selection approach based on genomic prediction has been developed to help plant breeders identify a set of superior parental lines from a candidate population before conducting field trials.
Ping-Yuan Chung, Chen-Tuo Liao
doaj   +1 more source

A Ranking Approach to Genomic Selection

PLOS ONE, 2015
Genomic selection (GS) is a recent selective breeding method which uses predictive models based on whole-genome molecular markers. Until now, existing studies formulated GS as the problem of modeling an individual's breeding value for a particular trait of interest, i.e., as a regression problem.
Mathieu Blondel, Akio Onogi, Hiroyoshi Iwata, Naonori Ueda   +3 more
openaire   +4 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source