Results 71 to 80 of about 3,428,811 (256)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Identification of superior parental lines for biparental crossing via genomic prediction.
PLoS ONE, 2020 A parental selection approach based on genomic prediction has been developed to help plant breeders identify a set of superior parental lines from a candidate population before conducting field trials.
Ping-Yuan Chung, Chen-Tuo Liao
doaj +1 more source
Genomic Selection in Animal Breeding [PDF]
Genomic selection endeavors to determine the reproductive values and characteristics of offspring in a given population through the utilization of high-density genetic markers. In contemporary breeding methods, classical approaches involve extended labor-
Hasan Batuhan Demircioglu +1 more
core +2 more sources
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
AnimalsGenomic selection (GS) is a technique that integrates genomic data, pedigree information, and individual phenotypes to enhance genetic improvements of economically important traits in livestock. While it has shown significant effects in dairy cattle, its
Le Zhou +7 more
doaj +1 more source
Multivariate Genomic Selection and Potential of Rapid Indirect Selection with Speed Breeding in Spring Wheat [PDF]
, 2019 Genomic selection (GS) can be effective in breeding for quantitative traits, such as yield, by reducing the selection cycle duration. Speed breeding (SB) uses extended photoperiod and temperature control to enable rapid generation advancement.
Jesse Poland +17 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Genomic selection in white clover
, 2020 Overview of Pastoral Genomics Clover Genomic Selection Training Population development presented to Agriseeds - Feb 9 ...
Andrew Griffiths (3440687)
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source