Results 71 to 80 of about 2,697,056 (259)

Estimating quantitative genetic parameters in wild populations:A comparison of pedigree and genomic approaches [PDF]

, 2014
The estimation of quantitative genetic parameters in wild populations is generally limited by the accuracy and completeness of the available pedigree information. Using relatedness at genome-wide markers can potentially remove this limitation and lead to
Pemberton, Josephine M, Ellis, Philip A., Pemberton, Josephine M., Bérénos, Camillo, Ellis, Philip A, Pilkington, Jill G., Pilkington, Jill G   +6 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Genomic prediction of survival traits for scuticociliatosis resistance in a vaccinated olive flounder cohort: Comprehensive evaluation and optimization of statistical and machine learning models

Aquaculture Reports
Genomic prediction utilizes genome-wide markers to facilitate genomic selection in aquaculture, enabling more precise and accelerated genetic gains compared to traditional pedigree-based methods.
Yasara Kavindi Kodagoda, Gaeun Kim, D.S. Liyanage, W.K.M. Omeka, Cheonguk Park, Jeongeun Kim, H.A.C.R. Hanchapola, M.A.H. Dilshan, D.C.G. Rodrigo, G.A.N.P. Ganepola, David B. Jones, Cecile Massault, Dean R. Jerry, Jihun Lee, Jehee Lee   +14 more
doaj   +1 more source

Turning science on robust cattle into improved genetic selection decisions

Animal, 2012
More robust cattle have the potential to increase farm profitability, improve animal welfare, reduce the contribution of ruminant livestock to greenhouse gas emissions and decrease the risk of food shortages in the face of increased variability in the ...
P.R. Amer
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Quality Evaluation, Phytochemical Characteristics and Estimation of Beta-Carotene Hydroxylase 2 (Chy2) Alleles of Interspecific Potato Hybrids

Agronomy, 2021
Potatoes contain antioxidants such as flavonoids, carotenoids and ascorbic acid. High level consumption worldwide makes potato a valuable source of phytonutrients. Developing new potato varieties with high nutritional value in combination with resistance
Oksana B. Polivanova, Ekaterina M. Gins, Evgeny A. Moskalev, Maria S. Voinova, Alina K. Koroleva, Anatoly Zh. Semenov, Anastasia B. Sivolapova, Anna S. Ivanova, Oleg G. Kazakov, Evgeny A. Simakov, Nadezhda A. Chalaya, Elena V. Rogozina, Svetlana V. Goryunova   +12 more
doaj   +1 more source

Multilevel selection on mitochondrial genomes

Current Opinion in Genetics & Development, 2023
Mitochondria are vital organelles for life in eukaryotes, taking centre stage in the process of cellular respiration. This process is regulated via a series of finely coordinated obligate interactions of molecules encoded by two genomes: nuclear DNA and mitochondrial DNA.
Camus, MF, Dhawanjewar, AS
openaire   +3 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Genome-wide association and genomic prediction of thermal tolerance in olive flounders (Paralichthys olivaceus): A validation study

Aquaculture Reports
Global warming poses a significant challenge to aquaculture, with increasing water temperatures adversely affecting the growth, reproduction, and survival of aquatic species.
H.M.V. Udayantha, Jeongeun Kim, Gaeun Kim, Jihun Lee, Sukkyoung Lee, Cheong-Uk Park, David B. Jones, Cecile Massault, Dean R. Jerry, D.S. Liyanage, Jehee Lee   +10 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source