Results 61 to 70 of about 616,505 (302)
Cell, 2010 GWAS: “G-whiz!” or “GWAShed-up”? Genome-wide association studies (GWASs) link single-nucleotide variations in the human genome to a complex trait. Over the past 4 years, these ground-breaking studies have identified almost 1000 alleles increasing an individual's risk for developing common diseases, such as cancer and obesity.
openaire +1 more source
Estimating quantitative genetic parameters in wild populations:A comparison of pedigree and genomic approaches [PDF]
, 2014 The estimation of quantitative genetic parameters in wild populations is generally limited by the accuracy and completeness of the available pedigree information. Using relatedness at genome-wide markers can potentially remove this limitation and lead to
Pemberton, Josephine M +6 more
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Fisheries and Aquatic SciencesThe mechanism for the elimination of xenobiotics undergoes three different phases of reactions in organisms. Among these, glutathione S-transferases (GSTs) are classified as phase II detoxification enzymes, catalyzing the conjugation of electrophilic ...
Jeongeun Kim +3 more
doaj +1 more source
Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas
Pediatric Blood &Cancer, EarlyView.ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall +2 more
wiley +1 more source
Genomic selection in dairy cattle [PDF]
, 2011 The objectives of this Ph.D. thesis were (1) to optimise genomic selection in dairy cattle with respect to the accuracy of predicting total genetic merit and (2) to optimise a dairy cattle breeding program using genomic selection. The study was performed
de Roos, A.P.W., Roos, A.P.W., de
core
Multivariate Genomic Selection and Potential of Rapid Indirect Selection with Speed Breeding in Spring Wheat [PDF]
, 2019 Genomic selection (GS) can be effective in breeding for quantitative traits, such as yield, by reducing the selection cycle duration. Speed breeding (SB) uses extended photoperiod and temperature control to enable rapid generation advancement.
Jesse Poland +17 more
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Genome-wide association studies on leaf midrib architecture in maize
Frontiers in Plant ScienceIntroductionLeaf midrib architecture (LMA) in maize plays essential roles in supporting leaf structure and facilitating photosynthetic performance. Despite its importance for plant architecture and yield potential, the genetic basis underlying key midrib
Dongdong Dang +8 more
doaj +1 more source
The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo +5 more
wiley +1 more source
Future trends in Animal Breeding due to new genetic tecnologies [PDF]
, 2011 The Darwin theory of evolution by natural selection is based on three principles: (a) variation; (b) inheritance; and (c) natural selection. Here, I take these principles as an excuse to review some topics related to the future research prospects in ...
Toro Ibañez, Miguel Angel
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The L-shaped selection algorithm for multitrait genomic selection [PDF]
, 2022 Selecting for multiple traits as opposed to a single trait has become increasingly important in genomic selection. As one of the most popular approaches to multitrait genomic selection, index selection uses a weighted average of all traits as a single ...
Wu, Ruoyu +3 more
core +2 more sources