Results 61 to 70 of about 984,187 (300)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Agriculture, 2022 Since its initial description in 2001, and with falling costs of genotyping, genomic selection has been implemented in a wide range of species. Theory predicts that the genomic selection approach to genetic improvement offers scope both for faster ...
Robert Banks
doaj +1 more source
Genomic prediction and quantitative trait locus discovery in a cassava training population constructed from multiple breeding stages [PDF]
, 2020 Open Access Article; Published online: 11 Dec 2019Assembly of a training population (TP) is an important component of effective genomic selection‐based breeding programs.
Egesi, C. +11 more
core +1 more source
Cell, 2009 Genomic plasticity is emerging as a mechanism of phenotypic variation both within individual organisms and across species over evolutionary time. This Genomics Select examines recently reported examples of genomic plasticity at work as well as the mechanisms for how one mode of genome alteration, transposition, is regulated.
openaire +1 more source
A Ranking Approach to Genomic Selection
PLOS ONE, 2015 Genomic selection (GS) is a recent selective breeding method which uses predictive models based on whole-genome molecular markers. Until now, existing studies formulated GS as the problem of modeling an individual's breeding value for a particular trait of interest, i.e., as a regression problem.
Mathieu Blondel +3 more
openaire +4 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
ImmunoDeep-sea mineral water (DSW) consists of different compositions and properties. The composition can be varied in different seas all around the world.
Hitihami M. S. M. Wijerathna +5 more
doaj +1 more source
Cell, 2010 GWAS: “G-whiz!” or “GWAShed-up”? Genome-wide association studies (GWASs) link single-nucleotide variations in the human genome to a complex trait. Over the past 4 years, these ground-breaking studies have identified almost 1000 alleles increasing an individual's risk for developing common diseases, such as cancer and obesity.
openaire +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source