Results 61 to 70 of about 3,428,811 (256)

Genomic prediction of survival traits for scuticociliatosis resistance in a vaccinated olive flounder cohort: Comprehensive evaluation and optimization of statistical and machine learning models

Aquaculture Reports
Genomic prediction utilizes genome-wide markers to facilitate genomic selection in aquaculture, enabling more precise and accelerated genetic gains compared to traditional pedigree-based methods.
Yasara Kavindi Kodagoda, Gaeun Kim, D.S. Liyanage, W.K.M. Omeka, Cheonguk Park, Jeongeun Kim, H.A.C.R. Hanchapola, M.A.H. Dilshan, D.C.G. Rodrigo, G.A.N.P. Ganepola, David B. Jones, Cecile Massault, Dean R. Jerry, Jihun Lee, Jehee Lee   +14 more
doaj   +1 more source

ICGRM: integrative construction of genomic relationship matrix combining multiple genomic regions for big dataset

BMC Bioinformatics, 2019
Background Genomic prediction is an advanced method for estimating genetic values, which has been widely accepted for genetic evaluation in animal and disease-risk prediction in human. It estimates genetic values with genome-wide distributed SNPs instead
Dan Jiang, Cong Xin, Jinhua Ye, Yingbo Yuan, Ming Fang   +4 more
doaj   +1 more source

Turning science on robust cattle into improved genetic selection decisions

Animal, 2012
More robust cattle have the potential to increase farm profitability, improve animal welfare, reduce the contribution of ruminant livestock to greenhouse gas emissions and decrease the risk of food shortages in the face of increased variability in the ...
P.R. Amer
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Genome-wide association and genomic prediction of thermal tolerance in olive flounders (Paralichthys olivaceus): A validation study

Aquaculture Reports
Global warming poses a significant challenge to aquaculture, with increasing water temperatures adversely affecting the growth, reproduction, and survival of aquatic species.
H.M.V. Udayantha, Jeongeun Kim, Gaeun Kim, Jihun Lee, Sukkyoung Lee, Cheong-Uk Park, David B. Jones, Cecile Massault, Dean R. Jerry, D.S. Liyanage, Jehee Lee   +10 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Comparative Transcriptome Analysis of White and Orange Skin of Clownfish Identifying Differentially Expressed Genes (DEGs) Underlying Pigment Expression

Fishes
Although the clownfish, Amphiprion ocellaris (A. ocellaris), is a popular ornamental marine fish worldwide, the mechanisms underlying color pattern variation remain unclear. Given that the Platinum-type clownfish, nearly entirely white, has high economic
Heegun Lee, Taehyug Jeong, Yeongkuk Kim, Sumi Jung, Jiyong Choi, Min-min Jung, Seunghwan Ko, Hayeong Oh, Juhyeok Kim, Jehee Lee, Seung Hwan Lee   +10 more
doaj   +1 more source