Results 131 to 140 of about 4,045,535 (372)
Genetics Selection Evolution, 2019 In France, implementation of genomic evaluations in dairy cattle breeds started in 2009 and this has modified the breeding schemes drastically. In this context, the goal of our study was to understand the impact of genomic selection on the genetic ...
Anna-Charlotte Doublet +7 more
semanticscholar +1 more source
Phenomic Selection: A New and Efficient Alternative to Genomic Selection
, 2022 AbstractRecently, it has been proposed to switch molecular markers to near-infrared (NIR) spectra for inferring relationships between individuals and further performing phenomic selection (PS), analogous to genomic selection (GS). The PS concept is similar to genomic-like omics-based (GLOB) selection, in which molecular markers are replaced by ...
Robert, Pauline +3 more
openaire +4 more sources
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
BMC Genomics, 2018 While autozygosity as a consequence of selection is well understood, there is limited information on the ability of different methods to measure true inbreeding.
M. Forutan +5 more
semanticscholar +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Highly Scalable Algorithms for Robust String Barcoding
, 2005 String barcoding is a recently introduced technique for genomic-based identification of microorganisms. In this paper we describe the engineering of highly scalable algorithms for robust string barcoding.
DasGupta, Bhaskar +3 more
core +2 more sources
Different models of genetic variation and their effect on genomic evaluation [PDF]
, 2011 Background The theory of genomic selection is based on the prediction of the effects of quantitative trait loci (QTL) in linkage disequilibrium (LD) with markers. However, there is increasing evidence that genomic selection also relies on "relationships"
Clark, S.A. +2 more
core +3 more sources
Sarcoptic mange severity is associated with reduced genomic variation and evidence of selection in Yellowstone National Park wolves (Canis lupus) [PDF]
, 2020 Alexandra L. DeCandia +4 more
openalex +1 more source
G3: Genes, Genomes, Genetics, 2018 Genomic selection applied to plant breeding enables earlier estimates of a line’s performance and significant reductions in generation interval. Several factors affecting prediction accuracy should be well understood if breeders are to harness genomic ...
Adam Norman +3 more
semanticscholar +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source