Results 141 to 150 of about 4,045,535 (372)

Introgression of a major QTL from an inferior into a superior population using genomic selection

open access: yesGenetics Selection Evolution, 2009
Background Selection schemes aiming at introgressing genetic material from a donor into a recipient line may be performed by backcross-breeding programs combined with selection to preserve the favourable characteristics of the donor population.
Yazdi M Hossein   +3 more
doaj   +1 more source

Improving "low input" dairy cattle production systems [PDF]

open access: yes, 2011
Thanks to developments in DNA sequencing technology, in recent years a growing amount of information on the genetic make-up of livestock animals have become available.
Biscarini, Filippo
core  

Non-additive Effects in Genomic Selection

open access: yesFrontiers in Genetics, 2018
In the last decade, genomic selection has become a standard in the genetic evaluation of livestock populations. However, most procedures for the implementation of genomic selection only consider the additive effects associated with SNP (Single Nucleotide
L. Varona   +3 more
semanticscholar   +1 more source

Evolutionary genomics and the reach of selection [PDF]

open access: yesJournal of Biology, 2009
Unexpected findings in evolutionary genomics both question the role of selection in genome evolution and clarify how genomes work.
openaire   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Genomic selection in maritime pine

open access: yesPlant Science, 2016
A two-generation maritime pine (Pinus pinaster Ait.) breeding population (n=661) was genotyped using 2500 SNP markers. The extent of linkage disequilibrium and utility of genomic selection for growth and stem straightness improvement were investigated. The overall intra-chromosomal linkage disequilibrium was r(2)=0.01.
Isik, Fikret   +7 more
openaire   +4 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Reliability of genomic evaluation for egg quality traits in layers

open access: yesBMC Genetics, 2020
Background Genomic evaluation, based on the use of thousands of genetic markers in addition to pedigree and phenotype information, has become the standard evaluation methodology in dairy cattle breeding programmes over the past several years. Despite the
David Picard Druet   +6 more
doaj   +1 more source

Optimizing Low-Cost Genotyping and Imputation Strategies for Genomic Selection in Atlantic Salmon

open access: yesG3: Genes, Genomes, Genetics, 2019
Genomic selection enables cumulative genetic gains in key production traits such as disease resistance, playing an important role in the economic and environmental sustainability of aquaculture production.
S. Tsairidou   +4 more
semanticscholar   +1 more source

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