Results 151 to 160 of about 4,045,535 (372)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Genomic breeding value prediction: methods and procedures*

Animal, 2010
Animal breeding faces one of the most significant changes of the past decades – the implementation of genomic selection. Genomic selection uses dense marker maps to predict the breeding value of animals with reported accuracies that are up to 0.31 higher
M.P.L. Calus
doaj   +1 more source

BWGS: A R package for genomic selection and its application to a wheat breeding programme

bioRxiv, 2019
We developed an integrated R library called BWGS to enable easy computation of Genomic Estimates of Breeding values (GEBV) for genomic selection. BWGS relies on existing R-libraries, all freely available from CRAN servers.
G. Charmet, L. Tran, J. Auzanneau, R. Rincent, S. Bouchet   +4 more
semanticscholar   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

An investigation of machine learning methods applied to genomic prediction in yellow-feathered broilers

Poultry Science
Machine learning (ML) methods have rapidly developed in various theoretical and practical research areas, including predicting genomic breeding values for large livestock animals.
Bogong Liu, Huichao Liu, Junhao Tu, Jian Xiao, Jie Yang, Xi He, Haihan Zhang   +6 more
doaj   +1 more source

Genomic analysis of worldwide sheep breeds reveals PDGFD as a major target of fat-tail selection in sheep [PDF]

, 2020
Kunzhe Dong, Min Yang, Jiangang Han, Qing Ma, Jilong Han, Ziyi Song, Cuicheng Luosang, Neena Amatya Gorkhali, Bohui Yang, Xiaohong He, Yuehui Ma, Lin Jiang   +11 more
openalex   +1 more source

Genome‐wide association and genomic selection in aquaculture

Reviews in Aquaculture, 2022
J. Yáñez, A. Barría, M. López, T. Moen, B. Garcia, G. Yoshida, Peng Xu   +6 more
semanticscholar   +1 more source

Genomic Selection for Growth Traits in Pacific Oyster (Crassostrea gigas): Potential of Low-Density Marker Panels for Breeding Value Prediction

Frontiers in Genetics, 2018
Pacific oysters are a key aquaculture species globally, and genetic improvement via selective breeding is a major target. Genomic selection has the potential to expedite genetic gain for key target traits of a breeding program, but has not yet been ...
Alejandro P. Gutiérrez, O. Matika, T. Bean, R. Houston   +3 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The Value of Expanding the Training Population to Improve Genomic Selection Models in Tetraploid Potato

Frontiers in Plant Science, 2018
Genomic selection (GS) is becoming increasingly applicable to crops as the genotyping costs continue to decrease, which makes it an attractive alternative to traditional selective breeding based on observed phenotypes. With genome-wide molecular markers,
E. Sverrisdóttir, Ea Høegh Riis Sundmark, H. Johnsen, H. Kirk, T. Asp, Lucas L. Janss, G. Bryan, K. Nielsen   +7 more
semanticscholar   +1 more source