Results 161 to 170 of about 4,045,535 (372)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Low density marker‐based effectiveness and efficiency of early‐generation genomic selection relative to phenotype‐based selection in dolichos bean (Lablab purpureus L. Sweet)

The Plant Genome
Genomic prediction has been demonstrated to be an efficient approach for the selection of candidates based on marker information in many crops. However, efforts to understand the efficiency of genomic selection over phenotype‐based selection in ...
Mugali Pundalik Kalpana, Sampangi Ramesh, Chindi Basavaraj Siddu, Gonal Basanagouda, K. Madhusudan, Hosakoti Sathish, Dinesh Sindhu, Munegowda Kemparaju, C. Anilkumar   +8 more
doaj   +1 more source

Hybrid breeding of rice via genomic selection

Plant Biotechnology Journal, 2019
Summary Hybrid breeding is the main strategy for improving productivity in many crops, especially in rice and maize. Genomic hybrid breeding is a technology that uses whole‐genome markers to predict future hybrids.
Yanru Cui, Ruidong Li, Guangwei Li, Fan Zhang, Tiantian Zhu, Qifa Zhang, J. Ali, Zhikang Li, Shizhong Xu   +8 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Genome-Wide Association and Genomic Selection for Resistance to Amoebic Gill Disease in Atlantic Salmon

G3: Genes, Genomes, Genetics, 2018
Amoebic gill disease (AGD) is one of the largest threats to salmon aquaculture, causing serious economic and animal welfare burden. Treatments can be expensive and environmentally damaging, hence the need for alternative strategies.
D. Robledo, Oswald Matika, A. Hamilton, R. Houston   +3 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Experimental validation of genomic selection in Sugarcane : P0197 [PDF]

, 2013
Sugarcane cultivars (Saccharum spp.) are interspecific hybrids characterized by highly heterozygous and polyploid genome. Genomic selection (GS) approach is believed to be well suited for complex traits by including all markers in prediction models.
Costet, Laurent, Gouy, Matthieu, Hoarau, Jean-Yves, Nibouche, Samuel, Rousselle, Yves   +4 more
core  

Empowering global rice breeding programs using genomic selection. [W291] [PDF]

, 2020
Rice is the staple food for half of the global population and irrigated rice contributes 70% of total rice produced. Given the strategic importance of this market segment to global food security, the irrigated rice breeding program at IRRI is mandated to
Arbelaez Velez, Juan David, Bartholome, Jérôme, Cobb, Joshua, Imee Zhella, Rose, Kumar Katiyar, Sanjay, Lopena, Vitaliano, Murori, Rosemary, Ndayiragije, Alexis, Prakash, Parthiban, Rafiqul, Mohammad, Rutkoski, Jessica, Verdeprado, Holden   +11 more
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Genomic Selection in Animal Breeding [PDF]

BIO Web of Conferences
Genomic selection endeavors to determine the reproductive values and characteristics of offspring in a given population through the utilization of high-density genetic markers. In contemporary breeding methods, classical approaches involve extended labor-
Demircioglu Hasan Batuhan
doaj   +1 more source