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Pathogens select for genomic variants
Science, 2017Malarial Genomics Large-scale deletions and duplications of genes, referred to as structural variants (SVs), are common within the human genome and have been linked to disease. Examining a genomic region that appears to confer a selective benefit, Leffler et al.
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Genomic selection in hybrid breeding
Plant Breeding, 2014AbstractWhile hybrid breeding is widely applied in outbreeding species, for many selfâpollinating crop plants, it has only recently been established. This may have had its reason in the limitations of methods available for hybrid performance prediction, in particular when established heterotic pools were absent.
Albert Wilhelm Schulthess +2 more
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Genomic selection: genome-wide prediction in plant improvement
Trends in Plant Science, 2014Association analysis is used to measure relations between markers and quantitative trait loci (QTL). Their estimation ignores genes with small effects that trigger underpinning quantitative traits. By contrast, genome-wide selection estimates marker effects across the whole genome on the target population based on a prediction model developed in the ...
Zeratsion Abera, Desta, Rodomiro, Ortiz
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Target Selection for Structural Genomics: A Single Genome Approach
OMICS: A Journal of Integrative Biology, 2002We describe our strategy for selecting targets for protein structure determination in context of structural genomics of a single genome. In the course of target selection, we have studied two the smallest microbial genomes, Mycoplasma genitalium and Mycoplasma ...
Igor V, Grigoriev, In-Geol, Choi
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Parameters affecting genome simulation for evaluating genomic selection method
Animal Science Journal, 2014AbstractThe present study investigated the parameter settings for obtaining a simulated genome at steady state of allele frequency (mutationâdrift equilibrium) and linkage disequilibrium (LD), and evaluated the impact of whether or not the simulated genome reached steady state of allele frequency and LD on the accuracy of genomic estimated breeding ...
Motohide, Nishio, Masahiro, Satoh
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A fast genomic selection approach for large genomic data
Theoretical and Applied Genetics, 2017We propose a novel computational method for genomic selection that combines identical-by-state (IBS)-based Haseman-Elston (HE) regression and best linear prediction (BLP), called HE-BLP. Genomic best linear unbiased prediction (GBLUP) has been widely used in whole-genome prediction for breeding programs.
Hailan, Liu, Guo-Bo, Chen
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Selecting Genomes for Reconstruction of Ancestral Genomes
2007It is often impossible to sequence all descendent genomes to reconstruct an ancestral genome. In addition, more genomes do not necessarily give a higher accuracy for the reconstruction of ancestral character states. These facts lead to studying the genome selection for reconstruction problem.
Guoliang Li, Jian Ma, Louxin Zhang
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