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Chromium and genomic stability [PDF]

open access: yesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2012
Many metals serve as micronutrients which protect against genomic instability. Chromium is most abundant in its trivalent and hexavalent forms. Trivalent chromium has historically been considered an essential element, though recent data indicate that while it can have pharmacological effects and value, it is not essential.
Sandra S Wise, John Pierce Wise
exaly   +3 more sources
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Epigenetics and genome stability

Mammalian Genome, 2020
Maintaining genome stability is essential to an organism's health and survival. Breakdown of the mechanisms protecting the genome and the resulting genome instability are an important aspect of the aging process and have been linked to diseases such as cancer. Thus, a large network of interconnected pathways is responsible for ensuring genome integrity
Justina X. Feng, Nicole C. Riddle
openaire   +2 more sources

The role of zinc in genomic stability

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2012
Zinc (Zn) is an essential trace element required for maintaining both optimal human health and genomic stability. Zn plays a critical role in the regulation of DNA repair mechanisms, cell proliferation, differentiation and apoptosis involving the action of various transcriptional factors and DNA or RNA polymerases.
Peter Zalewski   +2 more
exaly   +4 more sources

Genomic stability in reprogramming

Current Opinion in Genetics & Development, 2012
The genetic stability of induced pluripotent stem (iPS) cells has a significant impact on their potential use in regenerative medicine and basic research. Analysis of the genomic integrity of iPS cells suggests a tendency to develop aberrations ranging from whole chromosome trisomies to single nucleotide mutations. Furthermore, fluctuations in telomere
Daniel, Ronen, Nissim, Benvenisty
openaire   +2 more sources

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