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Genome (in)stability at tandem repeats
Seminars in Cell & Developmental Biology, 2021Repeat sequences account for over half of the human genome and represent a significant source of variation that underlies physiological and pathological states. Yet, their study has been hindered due to limitations in short-reads sequencing technology and difficulties in assembly.
Elisa Balzano +2 more
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Carotenoids and genomic stability
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001Epidemiological evidence abounds for a link between intake of carotenoids from fruit and vegetable foods and relatively low incidence of various cancers. However, intervention trials have shown, in some cases, a significant increase in occurrence of lung cancer in those volunteers taking supplements of beta-carotene.
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Chromosome segregation and genomic stability
Current Opinion in Genetics & Development, 2004The acquisition of genomic instability is a crucial step in the development of human cancer. Genomic instability has multiple causes of which chromosomal instability (CIN) and microsatellite instability (MIN) have received the most attention. Whereas the connection between a MIN phenotype and cancer is now proven, the argument that CIN causes cancer ...
Viji M, Draviam +2 more
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Genomic stability of gibbon oncornavirus
Journal of Virology, 1978The 70S RNAs from several gibbon type C viruses were examined for sequence homology by molecular hybridization using complementary DNA probes. The sequence homology was found to vary with each virus isolate. The genome from one isolate was examined for genomic stability after the virus was experimentally passaged through three unrelated gibbons.
L, Sun, T G, Kawakami, S I, Matoba
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Iron and genome stability: An update
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2012Iron is an essential micronutrient which is required in a relatively narrow range for maintaining metabolic homeostasis and genome stability. Iron participates in oxygen transport and mitochondrial respiration as well as in antioxidant and nucleic acid metabolism.
Daniel, Prá +3 more
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RAD51, genomic stability, and tumorigenesis
Cancer Letters, 2005Genomic instability is characteristic of malignant cells, and a strong correlation exists between abnormal karyotype and tumorigenicity. Increased expression of the homologous recombination and DNA repair protein Rad51 has been reported in immortalized cell lines and multiple primary tumor cell types which could alter recombination pathways to ...
Christine Richardson
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Role of magnesium in genomic stability
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001In cellular systems, magnesium is the second most abundant element and is involved in basically all metabolic pathways. At physiologically relevant concentrations, magnesium itself is not genotoxic, but is highly required to maintain genomic stability. Besides its stabilizing effect on DNA and chromatin structure, magnesium is an essential cofactor in ...
Andrea Hartwig
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Vitamin E and genome stability
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001Free radicals and reactive oxygen species (ROS) which are generated continuously cause mutagenic alterations resulting in cancer, aging and abnormalities in the nervous system. Accumulating evidence indicates that Vitamin E, the most potent lipid peroxyl radical scavenger, may reduce free radical induced chromosomal damages through inhibition of free ...
K J, Claycombe, S N, Meydani
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2007
Cancer results from a disordered and unstable genome - the degree of abnormality progresses as the process of oncogenesis proceeds. Such genomic instability appears to be subject to control by environmental factors as evidenced by the number of cancers that are either caused by specific environmental agents (lung, skin, cervix) or else regulated by a ...
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Cancer results from a disordered and unstable genome - the degree of abnormality progresses as the process of oncogenesis proceeds. Such genomic instability appears to be subject to control by environmental factors as evidenced by the number of cancers that are either caused by specific environmental agents (lung, skin, cervix) or else regulated by a ...
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Telomere dynamics in genome stability
Trends in Biochemical Sciences, 2006The past several years have seen an increasing interest in telomere recombinational interactions that provide many functions in telomere capping, in telomere size homeostasis and in overcoming the catastrophic effects of telomerase deficiency. Several key recombination mechanisms have emerged from recent investigations.
Mrinal K, Bhattacharyya +1 more
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