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Function of TopBP1 in Genome Stability
2009Human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and its orthologues in other organisms are proteins consisting of multiple BRCT modules that have acquired several functions during evolution. These proteins execute their tasks by interacting with a great variety of proteins involved in nuclear processes. TopBP1 is an essential protein that has
Miiko, Sokka +3 more
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Vitamin D and genomic stability
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 20011alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] has been shown to act on novel target tissues not related to calcium homeostasis. There have been reports characterizing 1,25(OH)(2)D(3) receptors and activities in diverse tissues such as brain, pancreas, pituitary, skin, muscle, placenta, immune cells and parathyroid.
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Copper and genomic stability in mammals
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001As the free ion and in the form of some complexes, there is no doubt that copper can promote damage to cellular molecules and structures through radical formation. At the same time, and perhaps as a consequence, mammals have evolved means of minimizing levels of free copper ions and destructive copper complexes that enter the organism and its cells ...
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Vitamin C and genomic stability
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001Vitamin C, a water-soluble glucose derivative, has considerable antioxidant activity in vitro, in part because of its ease of oxidation and because the semidehydroascorbate radical derived from it is of low reactivity. Vitamin C in vivo is an essential cofactor for a range of enzymes involved in diverse metabolic pathways, but much recent literature ...
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2016
Ageing is defined as the progressive attrition of tissue/organ function resulting in an increased susceptibility to disease and death. The DNA mutation and damage theory of ageing posits that the accrual of genetic damage over time is the underlying cause of ageing.
Aditi U. Gurkar +2 more
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Ageing is defined as the progressive attrition of tissue/organ function resulting in an increased susceptibility to disease and death. The DNA mutation and damage theory of ageing posits that the accrual of genetic damage over time is the underlying cause of ageing.
Aditi U. Gurkar +2 more
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Maintaining the Stability of the Genome
1996Ageing may be defined as the time-dependent general decline of physiological functions of an organism, which is associated with a progressively rising risk of morbidity and mortality. For many different types of cancer, for instance, old age is a very important, if not the single most important risk factor1.
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Decoy pumilio for genomic stability
Nature Reviews Molecular Cell Biology, 2016Eytan Zlotorynski
exaly
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
Nature Reviews Molecular Cell Biology, 2010Mary Ellen Moynahan, Maria Jasin
exaly