Results 141 to 150 of about 245,781 (306)

Pathogen Genomic Surveillance and Bioinformatics Training and Capacity Development Across Africa

International Journal of Infectious Diseases
Introduction: The recent emergence and re-emergence of infectious diseases across Africa have emphasised the critical need for vigorous pathogen genomic surveillance systems on the continent.
Ms Siddiqah George, Ms Kirsty Lee Garson, Mr Tony Yiquan Li, Mr Perceval Maturure, Professor Nicola Mulder   +4 more
doaj   +1 more source

Genomic surveillance strategy. Problems and perspectives

Journal of microbiology, epidemiology and immunobiology
The topic of epidemiologic surveillance is one of the basic concepts in the theory and practice of epidemiologic science. In Russia, generalization of the accumulated factual material and theoretical developments have allowed us to formulate a number of provisions on the nature of the epidemic process.
Vasily G. Akimkin, Tatyana A. Semenenko, Kamil F. Khafizov, Svetlana V. Ugleva, Dmitry V. Dubodelov, Elena N. Kolosovskaya   +5 more
openaire   +2 more sources

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

A response playbook for early detection and population surveillance of new SARS-CoV-2 variants in a regional public health laboratory

BMC Public Health
Background Timely genomic surveillance is required to inform public health responses to new SARS-CoV-2 variants. However, the processes involved in local genomic surveillance introduce inherent time constraints.
Hannah J. Barbian, Alyse Kittner, Richard Teran, Sofiya Bobrovska, Xueting Qiu, Kayla English, Stefan J. Green, Isaac Ghinai, Massimo Pacilli, Mary K. Hayden   +9 more
doaj   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Genomic epidemiology of SARS-CoV-2 in Bolivia, 2020–2024

Microbiology Spectrum
The COVID-19 pandemic has severely impacted Bolivia due to its high social vulnerability and limited healthcare resources. In response to the limited local capacity for genomic surveillance during the pandemic, we characterized the genetic diversity and ...
Esdenka Pérez-Cascales, Francesca Caballero, Anne Martínez-Ventura, Brenda Ayzanoa, Mauricio Prado-Zapata, Eliana Baldiviezo-Soliz, Paula Carballo-Jiménez, Freddy Tinajeros-Guzmán, Diego Cuicapuza, Pablo Tsukayama   +9 more
doaj   +1 more source

Use of Whole Genome Phylogeny and Comparisons in the Development of a Multiplex-PCR Assay to Identify Sequence Type 36 Vibrio parahaemolyticus [PDF]

, 2015
Vibrio parahaemolyticus sequence type (ST) 36 strains that are native to the Pacific Ocean have recently caused multi-state outbreaks of gastroenteritis linked to shellfish harvested from the Atlantic Ocean.
Cooper, Vaughn S., Hall, Jeffrey A., Ilyas, Saba, Jones, Stephen H., Siwakoti, Puskar, Whistler, Cheryl A., Xu, Feng   +6 more
core   +1 more source

Genomic surveillance of SARS-CoV-2 in Nepal

Microbiology Resource Announcements
ABSTRACT During the COVID-19 pandemic, Nepal, like other countries, faced emerging SARS-CoV-2 variants. To evaluate the circulating variants, 278 samples collected between September 2021 and March 2022 were sequenced in the country.
Binod Khadka, Rajindra Napit, Kathie A. Mihindukulasuriya, Smita Shrestha, Ramanuj Rauniyar, Eans T. Tuladhar, Lindsay Droit, Anne M. Paredes, Runa Jha, Roji Raut, Bimalesh K. Jha, Scott A. Handley, Annie Elong-Ngono, Sujan Shresta, David Wang, Krishna D. Manandhar   +15 more
openaire   +3 more sources