Results 41 to 50 of about 178,565 (255)

Stability of a stochastically perturbed model of intracellular single-stranded RNA virus replication

open access: yes, 2019
Replication of single-stranded RNA virus can be complicated, compared to that of double-stranded virus, as it require production of intermediate antigenomic strands that then serve as template for the genomic-sense strands.
Elena, Santiago F.   +2 more
core   +1 more source

Genetic dissection of the RNA polymerase II transcription cycle

open access: yeseLife, 2022
How DNA sequence affects the dynamics and position of RNA Polymerase II (Pol II) during transcription remains poorly understood. Here, we used naturally occurring genetic variation in F1 hybrid mice to explore how DNA sequence differences affect the ...
Shao-Pei Chou   +4 more
doaj   +1 more source

Glycinebetaine reduces oxidative injury and enhances fluoride stress tolerance via improving antioxidant enzymes, proline and genomic template stability in Cajanus cajan L.

open access: yesSouth African Journal of Botany, 2017
Abstract Excess of fluoride (F) in irrigation water is a serious threat inducing variety of deleterious impacts in plants via over-production of active oxygen species (AOS), modifying antioxidant enzymes and nucleic acid. Present study was aimed to monitor protective functions of glycinebetaine (GB) against F-toxicity in Cajanus cajan L. GB is an
B. Yadu   +3 more
openaire   +1 more source

Protecting exons from deleterious R-loops: a potential advantage of having introns

open access: yesBiology Direct, 2007
Background Accumulating evidence indicates that the nascent RNA can invade and pair with one strand of DNA, forming an R-loop structure that threatens the stability of the genome. In addition, the cost and benefit of introns are still in debate.
Niu Deng-Ke
doaj   +1 more source

Using the CRISPR/Cas9 system to understand neuropeptide biology and regulation [PDF]

open access: yes, 2016
Funding was provided by a Wellcome Trust ISSF starting grant (105625/Z/14/Z), Medical Research Scotland (PhD-719-2013), GW Pharmaceuticals (PhD-719-2013 - S.5242.001) and the BBSRC (BB/J012343/1).Peer reviewedPublisher ...
Hay, Elizabeth A   +3 more
core   +1 more source

Determination of cytogenetic and epigenetic effects of manganese and copper on Zea mays L.

open access: yesISPEC Journal of Agricultural Sciences, 2021
Heavy metal accumulation and its possible effects are prominent problem for not only human health but also for the environment and plant systems due to that heavy metals are non-biodegradable.
Filiz AYGÜN ERTÜRK   +2 more
doaj   +1 more source

Initiator tRNA genes template the 3\u27 CCA end at high frequencies in bacteria. [PDF]

open access: yes, 2016
BACKGROUND: While the CCA sequence at the mature 3\u27 end of tRNAs is conserved and critical for translational function, a genetic template for this sequence is not always contained in tRNA genes.
Ardell, David H., Hou, Ya-Ming
core   +3 more sources

Application of DNA (RAPD) and ultrastructure to detect the effect of cadmium stress in Egyptian clover and Sudan grass plantlets [PDF]

open access: yesJournal of Stress Physiology & Biochemistry, 2012
BackgroundIn recent years, several plant species have been used as bioindicators to evaluate the toxicity of environmental contaminants on vegetal organisms.
Amina A. Aly
doaj  

Mycobacterium Time-Series Genome Analysis Identifies AAC2′ as a Potential Drug Target with Naloxone Showing Potential Bait Drug Synergism

open access: yesMolecules, 2022
The World Health Organization has put drug resistance in tuberculosis on its list of significant threats, with a critical emphasis on resolving the genetic differences in Mycobacterium tuberculosis. This provides an opportunity for a better understanding
Vidya Niranjan   +5 more
doaj   +1 more source

DNA DSB repair pathway choice: an orchestrated handover mechanism [PDF]

open access: yes, 2014
DNA double strand breaks (DSBs) are potential lethal lesions but can also lead to chromosome rearrangements, a step promoting carcinogenesis. DNA non-homologous end-joining (NHEJ) is the major DSB rejoining process and occurs in all cell cycle stages ...
A Kakarougkas   +5 more
core   +1 more source

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