Results 51 to 60 of about 178,565 (255)

The chromatin assembly factor 1 promotes Rad51-dependent template switches at replication forks by counteracting D-loop disassembly by the RecQ-type helicase Rqh1.

PLoS Biology, 2014
At blocked replication forks, homologous recombination mediates the nascent strands to switch template in order to ensure replication restart, but faulty template switches underlie genome rearrangements in cancer cells and genomic disorders ...
Violena Pietrobon, Karine Fréon, Julien Hardy, Audrey Costes, Ismail Iraqui, Françoise Ochsenbein, Sarah A E Lambert   +6 more
doaj   +1 more source

QUALITATIVE ASSESSMENT OF CADMIUM STRESS USING GENOME TEMPLATE STABILITY IN Hordeum vulgare

Egyptian Journal of Genetics and Cytology, 2010
Cadmium, a non essential heavy metal, does not play any metabolic role and is considered as toxic element even at very low concentration. It is mainly generated through anthropogenic activities, such as mining deposits, aerial fallout from smelters and from industrial, agricultural, energy and municipal sources (McGrath et al., 2001; McBride, 2003 ...
openaire   +1 more source

Analysis of nucleosome positioning landscapes enables gene discovery in the human malaria parasite Plasmodium falciparum. [PDF]

, 2015
BackgroundPlasmodium falciparum, the deadliest malaria-causing parasite, has an extremely AT-rich (80.7 %) genome. Because of high AT-content, sequence-based annotation of genes and functional elements remains challenging.
Bunnik, Evelien M, Le Roch, Karine G, Lonardi, Stefano, Lu, Xueqing Maggie, Nasseri, Sara, Pokhriyal, Neeti   +5 more
core   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

The Impact of Zinc Oxide Nanoparticles on Cytotoxicity, Genotoxicity, and miRNA Expression in Barley (Hordeum vulgare L.) Seedlings

The Scientific World Journal, 2020
Zinc oxide nanoparticles are one of the most commonly engineered nanomaterials and necessarily enter the environment because of the large quantities produced and their widespread application. Understanding the impacts of nanoparticles on plant growth and
Ilona Plaksenkova, Inese Kokina, Anastasija Petrova, Marija Jermaļonoka, Vjačeslavs Gerbreders, Marina Krasovska   +5 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Application of Nucleic Acid Reference Material for Rapid Detection of Cronobacter sakazakii (Cronobacter spp.) in Flammulina velutipes

Journal of Food Quality, 2020
Cronobacter sakazakii (C. sakazakii) widely exists in the environment and is a common foodborne pathogenic microorganism. It can cause meningitis, bacteremia, and necrotizing enterocolitis in infants and elderly people with low immunity.
Huandie Yang, Danyang Guo, Leilei Chen, Alexander Suvorov, Qingxin Zhou, Junhua Wang, Xiaofeng Gao, Jinyu Yang, Xiangyan Chen   +8 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Heavy Metals Pollution and its Genotoxicity Assessment through the Green Marine Ulva lactuca (Chlorophyceae) Algae in the Lattakia-Coastline, Syria [PDF]

Journal of Stress Physiology & Biochemistry, 2020
The current study was conducted to investigate pollution level in Lattakia-coastline, Syria using Ulva lactuca (Chlorophyta) algae as bioindicator for sea water pollution based on Zn, Pb, Cu and Cd concentration using Atomic Absorption Spectrometry (AAS)
Basel Saleh
doaj  

Satellite DNA as a target for TaqMan real-time PCR detection of the pinewood nematode, Bursaphelenchus xylophilus [PDF]

, 2007
The pinewood nematode (PWN), Bursaphelenchus xylophilus , is a major pathogen of conifers, which impacts on forest health, natural ecosystem stability and international trade. As a consequence, it has been listed as a quarantine organism in Europe.
BOONHAM, NEIL, CASTAGNONE, CHANTAL, CASTAGNONE-SERENO, PHILIPPE, CECILE, FRANÇOIS, HOCKLAND, SUE, LAWSON, REBECCA, Mota, Manuel, QUILL, JAMES, TOMLINSON, JENNY, VIEIRA, Paulo   +9 more
core   +1 more source