Results 101 to 110 of about 1,430,606 (347)

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Responsible genomes: How can we foster responsible innovation in synthetic genomics?

Journal of Responsible Innovation
Reflections on the responsible development of synthetic genomics have contributed to shaping Responsible Research and Innovation (RRI) as an area of inquiry.
Paolo Corsico, Philip Shapira
doaj   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Genomics and Public Health: Development of Web-based Training

Preventing Chronic Disease, 2005
In 2001, the Centers for Disease Control and Prevention funded three Centers for Genomics and Public Health to develop training tools for increasing genomic awareness.
Janice V. Bach, MS, Aaron Goldenberg, MA, MPH, Toby Citrin, JD, Sarah F. Raup, MPH, Jennifer Bodzin, MPH, Sharon L.R. Kardia, PhD   +5 more
doaj  

The Brassica genome

Frontiers in Plant Science, 2013
BRASSICA GENOME RESEARCH TOPIC Brassica species include important crops and provide unique materials for the study of genome evolution. These crops include six important vegetables and oilseed crops, which have been classically described by “U’s triangle’. The three diploid species B. rapa (A genome), B. nigra (B genome), and B.
Michael Freeling, Xiaowu Wang
openaire   +4 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Preparing tomorrow's doctors for the genomics era: A nationwide survey of UK medical students

Future Healthcare Journal
Introduction: Low confidence in genomics knowledge among clinicians is a major barrier to the integration of genomics into mainstream medicine. Here, we assessed the genomics confidence of UK medical students approaching graduation. Methods: We conducted
Lydia Seed, Anna Scott, Michelle Peter, Shereen Tadros, Melissa Hill, Cristine Sortica da Costa   +5 more
doaj  

Lipid Metabolism and Comparative Genomics [PDF]

, 2006
Unilever asked the Study Group to focus on two problems. The first concerned dysregulated lipid metabolism which is a feature of many diseases including metabolic syndrome, obesity and coronary heart disease.
Jones, Janette, Melrose, John, O’Malley, Brendan, Pickersgill, Laura, Rougier, Jonathan, Tindall, Marcus   +5 more
core  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Understanding Ethical, Legal and Societal Issues (ELSIs) in Human Biobanking and Genomics for Research and Healthcare in Zimbabwe: The Genomics Inheritance Law Ethics and Society (GILES) initiative [version 2; peer review: 2 approved]

AAS Open Research, 2019
Biobanks and human genomics applications are key for understanding health, disease and heredity in Africa and globally. Growing interest in these technologies calls for strengthening relevant legal, ethical and policy systems to address knowledge ...
Alice Matimba, Andrew Chimatira, Oppah Kuguyo, James January, Zivayi Mupambireyi, Bazondlile Marimbe-Dube, Vasco Chikwasha, Zibusiso Nyati-Jokomo, Shamiso Muteti, Pedzisayi Mangezvo, Abigail Kangwende, Alfred Chingono, Midion Chidzonga, Jonathan Gandari, James Hakim, Kusum Nathoo, Christopher Samkange, Walter Mangezi, Sandra Lee, Lovemore Gwanzura, Mildred Cho, Paul Ndebele   +21 more
doaj   +1 more source