Results 81 to 90 of about 1,315,416 (283)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A qualitative study of genomics in cancer control for Aboriginal and Torres Strait Islander Australians

Australian and New Zealand Journal of Public Health
Objective: To describe the perspectives of Aboriginal and Torres Strait Islander peoples and health care workers on genomics in cancer care to inform the National Framework for Genomics in Cancer Control (the Framework). Methods: A total of 37 Aboriginal
Justine Clark, Jacinta Elston, Kelly Trudgen, Lucy Coulter, Carolyn Der Vartanian, Ashleigh R. Sharman, Claire Howlett, Vivienne Milch, Dorothy Keefe, Alex Brown   +9 more
doaj   +1 more source

The Collaborative African Genomics Network (CAfGEN): Applying Genomic technologies to probe host factors important to the progression of HIV and HIV-tuberculosis infection in sub-Saharan Africa [version 2; peer review: 2 approved]

AAS Open Research, 2018
Background: Here, we describe how the Collaborative African Genomics Network (CAfGEN) of the Human Heredity and Health in Africa (H3Africa) consortium is using genomics to probe host genetic factors important to the progression of HIV and HIV ...
Gerald Mboowa, Savannah Mwesigwa, Eric Katagirya, Gaone Retshabile, Busisiwe C. Mlotshwa, Lesedi Williams, Adeodata Kekitiinwa, David Kateete, Eddie Wampande, Misaki Wayengera, Betty Nsangi Kintu, Grace P. Kisitu, Samuel Kyobe, Chester W. Brown, Neil A. Hanchard, Graeme Mardon, Moses Joloba, Gabriel Anabwani, Ed Pettitt, Masego Tsimako-Johnstone, Ishmael Kasvosve, Koketso Maplanka, Sununguko W. Mpoloka, Makhosazana Hlatshwayo, Mogomotsi Matshaba   +24 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Lipid Metabolism and Comparative Genomics [PDF]

, 2006
Unilever asked the Study Group to focus on two problems. The first concerned dysregulated lipid metabolism which is a feature of many diseases including metabolic syndrome, obesity and coronary heart disease.
Jones, Janette, Melrose, John, O’Malley, Brendan, Pickersgill, Laura, Rougier, Jonathan, Tindall, Marcus   +5 more
core  

GenColors: Annotation and comparative genomics made easy [PDF]

, 2009
GenColors is a web-based software/database system initially aimed at an improved and accelerated annotation of prokaryotic genomes making extensive use of genome comparison (Romualdi et al., _Bioinformatics_ 2005; Romualdi et al., _Methods Mol.
Alessandro Romualdi, Gernot Gloeckner, Juergen Suehnel, Marius Felder, Matthias Platzer   +4 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Building International Genomics Collaboration for Global Health Security

Frontiers in Public Health, 2015
Genome science and technologies are transforming life sciences globally in many ways, and becoming a highly desirable area for international collaboration to strengthen global health.
Helen H Cui, Tracy eErkkila, Patrick S G Chain, Momchilo eVuyisich   +3 more
doaj   +1 more source

Conservation genomics [PDF]

Proceedings of the National Academy of Sciences, 2014
A female northern white rhinoceros, Ceratotherium simum cottoni, one of only seven remaining individuals of a form of African rhinoceros on the verge of extinction. Image courtesy of San Diego Zoo Global.
openaire   +2 more sources

Plant genomics – a way forward? [PDF]

, 2002
This report was presented at the UK Organic Research 2002 Conference. Diseases of plants cause significant losses in crop yield and quality. Plants contain a battery of genes whose role is to prevent pathogens invading. Their effective use in crop plants
Beynon, Jim
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