Results 61 to 70 of about 821,457 (264)

Connecticut BRFSS genomics brief

open access: yes, 2014
1 online resource (4 pages) : color illustrationsAt head of title: Connecticut BRFSS genomics brief; "February 2014."; Includes bibliographical references (page ...
Foland, Joan, author
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Genomics and the intrinsic value of plants [PDF]

open access: yes, 2005
7 pages.Debates the ethical issues of plant genomics with respect to the intrinsic value of ...
Gremmen, Bart
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

PUBLIC HEALTH GENOMICS: THE ESSENTIALS

open access: yes, 2008
Tables and figures -- Foreword -- Preface -- The authors -- Introduction -- Pt. 1. Scientific and social perspectives on genomics -- Ch. 1. Past, present, and future of public health genomics -- Ch. 2. Genomics and the government -- Ch. 3.
Mikail, Claudia N.
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Routledge Handbook of Genomics, Health and Society

open access: yes, 2018
The Handbook provides an essential resource at the interface of Genomics, Health and Society, and forms a crucial research tool for both new students and established scholars across biomedicine and social sciences.

core  

Generalized genetical genomics : advanced methods and applications [PDF]

open access: yes, 2010
Generalized genetical genomics (GGG) is a systems genetics approach that combines the analysis of genetic variation with population-wide assessment of variation in molecular traits in multiple environments to identify genotype-by-environment interactions.
Li, Yang,, Li, Yang
core   +16 more sources

Functional genomics in Spiralia

open access: yes, 2023
Our understanding of the mechanisms that modulate gene expression in animals is strongly biased by studying a handful of model species that mainly belong to three groups: Insecta, Nematoda and Vertebrata.
Billie E Davies   +9 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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