Results 61 to 70 of about 927,032 (316)

Developing leadership competencies for genomics integration through globally networked learning and education

Frontiers in Medicine
AimTo describe the implementation and evaluation of an education strategy called the globally networked learning-genomics (GNL-G) used in Master’s courses in Canada and Finland.
Jacqueline Limoges, Arja Halkoaho, Mari Laaksonen, Muskaan Karwal   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

How do citizens experience vulnerability in genomics?

, 2022
In the context of healthcare, and more specifically in genomics, the concept of vulnerability has been studied principally for particularly vulnerable groups and from the perspective of patients in the clinical context.
W. Van Hoof, H. Mertes, C. Mayeur
core  

Deep Learning of radiology-genomics integration for computational oncology: A mini review

Computational and Structural Biotechnology Journal
In the field of computational oncology, patient status is often assessed using radiology-genomics, which includes two key technologies and data, such as radiology and genomics.
Feng-ao Wang, Yixue Li, Tao Zeng
doaj   +1 more source

Can an infectious disease genomics project predict and prevent the next pandemic? [PDF]

PLoS Biology, 2009
The world of genomics is transforming medicine, and is likely to influence the future development of new drugs, diagnostics, and vaccines. To date, the greater focus of genomics and medicine has been on conditions affecting resourcewealthy settings ...
Rajesh Gupta, Mark H Michalski, Frank R Rijsberman   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Cancer genomic resources and present needs in the latin american region

, 2020
In Latin America (LA), cancer is the second leading cause of death, and little is known about the capacities and needs for the development of research in the field of cancer genomics.
Oliver, Javier, Díaz Velásquez, Clara Estela, Quezada-Urbán, Rosalía, Vaca Paniagua, Felipe, Torres, Ángela, Montealegre Paez, Ana Lorena, Frecha, Cecilia, Perdomo Lara, Sandra Janneth   +7 more
core   +1 more source

Life: Computational Genomics Applications in Life Sciences

, 2021
This Special Issue, “Life: Computational Genomics”, presents research articles on systems biology applications, computational genomics, and bioinformatics methods in life sciences [...
Yuriy L. Orlov, Anastasia A. Anashkina, Anashkina A.A., Orlov Y.L.   +3 more
core   +1 more source

Highlights on the Application of Genomics and Bioinformatics in the Fight Against Infectious Diseases: Challenges and Opportunities in Africa

Frontiers in Genetics, 2018
Genomics and bioinformatics are increasingly contributing to our understanding of infectious diseases caused by bacterial pathogens such as Mycobacterium tuberculosis and parasites such as Plasmodium falciparum. This ranges from investigations of disease
Saikou Y. Bah, Saikou Y. Bah, Collins Misita Morang’a, Jonas A. Kengne-Ouafo, Lucas Amenga–Etego, Gordon A. Awandare   +5 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source