Results 41 to 50 of about 1,315,416 (283)

Highlights on the Application of Genomics and Bioinformatics in the Fight Against Infectious Diseases: Challenges and Opportunities in Africa

Frontiers in Genetics, 2018
Genomics and bioinformatics are increasingly contributing to our understanding of infectious diseases caused by bacterial pathogens such as Mycobacterium tuberculosis and parasites such as Plasmodium falciparum. This ranges from investigations of disease
Saikou Y. Bah, Saikou Y. Bah, Collins Misita Morang’a, Jonas A. Kengne-Ouafo, Lucas Amenga–Etego, Gordon A. Awandare   +5 more
doaj   +1 more source

Combinations of genes at the 16p11.2 and 22q11.2 CNVs contribute to neurobehavioral traits.

PLoS Genetics, 2023
The 16p11.2 and 22q11.2 copy number variants (CNVs) are associated with neurobehavioral traits including autism spectrum disorder (ASD), schizophrenia, bipolar disorder, obesity, and intellectual disability.
Mikhail Vysotskiy, Autism Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Lauren A Weiss   +4 more
doaj   +1 more source

Towards a bioinformatics platform for the Musa research community : [Abstract W076] [PDF]

, 2010
Current experiments in genomics produce a large amount of data that needs to be organized into databases and broadly accessible. Like other species, the Musa genomics community would benefit from centralized and innovative ways to study its genome.
Argout, Xavier, Bocs, Stéphanie, Conte, Matthieu, Droc, Gaëtan, Guignon, Valentin, Hamelin, Chantal, Rouard, Mathieu, Roux, Nicolas, Ruiz, Manuel   +8 more
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The Genome Explorer genome browser

mSystems
ABSTRACT Are two adjacent genes in the same operon? What are the order and spacing between several transcription factor binding sites? Genome browsers are software data visualization and exploration tools that enable biologists to answer questions such as these.
James Herson, Markus Krummenacker, Aaron Spaulding, Paul O'Maille, Peter D. Karp   +4 more
openaire   +3 more sources

Public Health Genomics: The Essentials. By Claudia N. Mikail [PDF]

, 2009
The sequencing of the human genome in 2001 provided researchers, clinicians, policymakers, ethicists, and public health practitioners with a myriad of information to potentially improve disease outcomes on an individual and population basis.
Caron, Rosemary M
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Developing leadership competencies for genomics integration through globally networked learning and education

Frontiers in Medicine
AimTo describe the implementation and evaluation of an education strategy called the globally networked learning-genomics (GNL-G) used in Master’s courses in Canada and Finland.
Jacqueline Limoges, Arja Halkoaho, Mari Laaksonen, Muskaan Karwal   +3 more
doaj   +1 more source

Can an infectious disease genomics project predict and prevent the next pandemic? [PDF]

PLoS Biology, 2009
The world of genomics is transforming medicine, and is likely to influence the future development of new drugs, diagnostics, and vaccines. To date, the greater focus of genomics and medicine has been on conditions affecting resourcewealthy settings ...
Rajesh Gupta, Mark H Michalski, Frank R Rijsberman   +2 more
doaj   +1 more source

Genomic selection [PDF]

Journal of Animal Breeding and Genetics, 2007
SummaryGenomic selection is a form of marker‐assisted selection in which genetic markers covering the whole genome are used so that all quantitative trait loci (QTL) are in linkage disequilibrium with at least one marker. This approach has become feasible thanks to the large number of single nucleotide polymorphisms (SNP) discovered by genome ...
Goddard, M. E., Hayes, B. J.
openaire   +3 more sources