Results 51 to 60 of about 1,430,518 (311)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A genomics learning framework for undergraduates.
PLoS ONEGenomics is an increasingly important part of biology research. However, educating undergraduates in genomics is not yet a standard part of life sciences curricula.
Laura K Reed +8 more
doaj +1 more source
Frontiers in Public HealthIntroductionPathogen genomics, where whole genome sequencing technologies are used to produce complete genomic sequences of pathogens, is being increasingly used for infectious disease surveillance and outbreak response. Although proof-of-concept studies
James D. H. Ong +8 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Applications of Support Vector Machine (SVM) Learning in Cancer Genomics.
Cancer Genomics & Proteomics, 2018 Machine learning with maximization (support) of separating margin (vector), called support vector machine (SVM) learning, is a powerful classification tool that has been used for cancer genomic classification or subtyping.
Shujun Huang +5 more
semanticscholar +1 more source
Frontiers in Genetics, 2018 Genomics and bioinformatics are increasingly contributing to our understanding of infectious diseases caused by bacterial pathogens such as Mycobacterium tuberculosis and parasites such as Plasmodium falciparum. This ranges from investigations of disease
Saikou Y. Bah +5 more
doaj +1 more source
Combinations of genes at the 16p11.2 and 22q11.2 CNVs contribute to neurobehavioral traits.
PLoS Genetics, 2023 The 16p11.2 and 22q11.2 copy number variants (CNVs) are associated with neurobehavioral traits including autism spectrum disorder (ASD), schizophrenia, bipolar disorder, obesity, and intellectual disability.
Mikhail Vysotskiy +4 more
doaj +1 more source
Worm, 2014 Caenorhabditis elegans (C. elegans) nematodes transmit small RNAs across generations, a process that enables transgenerational regulation of genes. In contrast to changes to the DNA sequence, transgenerational transmission of small RNA-mediated responses is reversible, and thus enables "soft" or "flexible" inheritance of acquired characteristics. Until
Anava S, Posner R, Rechavi O.
openaire +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
The Nucleotide Transformer: Building and Evaluating Robust Foundation Models for Human Genomics
bioRxivClosing the gap between measurable genetic information and observable traits is a longstanding challenge in genomics. Yet, the prediction of molecular phenotypes from DNA sequences alone remains limited and inaccurate, often driven by the scarcity of ...
Hugo Dalla-torre +13 more
semanticscholar +1 more source