Results 71 to 80 of about 821,457 (264)
Foundations of Computational Mathematics, 2016 This work gives a mathematical foundation for bifurcation from a stable equilibrium in the genome. We construct idealized dynamics associated with the genome. For this dynamics we investigate the two main bifurcations from a stable equilibrium. Finally, we give a mathematical framework for the Repressilator and the Toggle gene circuits.
Indika Rajapakse, Steve Smale
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GENOMICS AND CLINICAL MEDICINE
, 2008 Contributors -- Pt. I. General genomics -- 1. From genes to genomes: a historical perspective / Ian Dunham and Don Powell -- 2. The human genome: structure and organization / Andrew Read -- 3. Human functional genomics and proteomics / Yoshiji Yamada,
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
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Chapter 28 Genomics in emerging and developing economies [PDF]
, 2018 Low and middle-income countries have become a site of increasing research interest and investment with the transnational expansion and spread of genomic knowledge and technologies (Kumar 2012, Seguin et al. 2008).
Gibbon, Sahra, Fullwiley, Duana
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Genomics in the UK: mapping the social science landscape
, 2006 This paper has been prepared from the perspective of the ESRC Genomics Policy & Research Forum, which has the particular mandate of linking social science research on genomics with ongoing public and policy debates.
Suk, Jonathan E., Banner, Michael
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
GENOMICS AND PUBLIC HEALTH: LEGAL AND SOCIO-ETHICAL PERSPECTIVES
, 2007 Acknowledgements -- Pt. I. Population screening: issues, realities and possibilities -- A Introduction: expansion of screening / J. Gerard Loeber -- Expansion of newborn screening: current achievements and new prospects / Bridget Wilcken ...
Knoppers, Bartha Maria, ed.
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