Results 81 to 90 of about 2,009,718 (421)

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Genomic signatures and gene networking: challenges and promises

BMC Genomics, 2011
This is an editorial report of the supplement to BMC Genomics that includes 15 papers selected from the BIOCOMP'10 - The 2010 International Conference on Bioinformatics & Computational Biology as well as other sources with a focus on genomics studies ...
Zhang Ke, Pirooznia Mehdi, Arabnia Hamid R, Yang Jack Y, Wang Liangjiang, Luo Zuojie, Deng Youping   +6 more
doaj   +1 more source

A review of deep learning applications in human genomics using next-generation sequencing data

Human Genomics, 2022
Genomics is advancing towards data-driven science. Through the advent of high-throughput data generating technologies in human genomics, we are overwhelmed with the heap of genomic data.
Wardah Alharbi, M. Rashid
semanticscholar   +1 more source

Genomics and synthetic biology as a viable option to intensify sustainable use of biodiversity [PDF]

, 2011
The Amazon basin is an area of mega-biodiversity. Different models have been proposed^1-8^ for the establishment of an effective conservation policy, increasing sustainability and adding value for biodiversity. Currently, a broad spectrum of technologies
Elibio L. Rech
core   +3 more sources

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Blast2GO: A Comprehensive Suite for Functional Analysis in Plant Genomics

International Journal of Plant Genomics, 2007
Functional annotation of novel sequence data is a primary requirement for the utilization of functional genomics approaches in plant research. In this paper, we describe the Blast2GO suite as a comprehensive bioinformatics tool for functional annotation ...
A. Conesa, Stefan Götz
semanticscholar   +1 more source

The Ectocarpus Genome and Brown Algal Genomics

, 2012
Brown algae are important organisms both because of their key ecological roles in coastal ecosystems and because of the remarkable biological features that they have acquired during their unusual evolutionary history. The recent sequencing of the complete genome of the filamentous brown alga Ectocarpus has provided unprecedented access to the molecular
Colin Brownlee, Betsy A. Read, Hiroshi Kawai, Stefan A. Rensing, Sylvie Doulbeau, Patrick Wincker, Bank Beszteri, Bank Beszteri, Florian Maumus, Chris Bowler, Martina Strittmatter, John H. Bothwell, John H. Bothwell, John H. Bothwell, Taizo Motomura, Véronique Anthouard, Pascal J. Lopez, Thierry Tonon, Thierry Tonon, Martin Lohr, Erwan Corre, Carolyn A. Napoli, Catherine Leblanc, Catherine Leblanc, Olivier Godfroy, Olivier Godfroy, Takahiro Yamagishi, Claire Jubin, Corinne Da Silva, Alok Arun, Alok Arun, Hadi Quesneville, Simon M. Dittami, Simon M. Dittami, Julie Poulain, Akira F. Peters, Akira F. Peters, Eric Bonnet, Eric Bonnet, Julia Morales, Julia Morales, Grigoris D. Amoutzias, Grigoris D. Amoutzias, Hervé Moreau, Philippe Potin, Philippe Potin, Remy Luthringer, Remy Luthringer, James W. Tregear, Cindy Martens, Daniel Lang, Claire M. M. Gachon, Gurvan Michel, Gurvan Michel, J. Mark Cock, J. Mark Cock, Garry Farnham, Jonathan H. Badger, Svenja Heesch, Svenja Heesch, Sophia Ahmed, Sophia Ahmed, Pierre Rouzé, Ga Youn Cho, Ga Youn Cho, Marek Eliáš, Laurence Dartevelle, Laurence Dartevelle, Peter von Dassow, Patrice Lerouge, Nicolas Macaisne, Nicolas Macaisne, Yves Van de Peer, David R. Nelson, Carl J. Carrano, Ludovic Delage, Ludovic Delage, Frithjof C. Küpper, Frithjof C. Küpper, François Artiguenave, Delphine Scornet, Delphine Scornet, Andrés Ritter, Andrés Ritter, Andrés Ritter, Manoj P. Samanta, Bénédicte Charrier, Bénédicte Charrier, Kamel Jabbari, Chikako Nagasato, Jean-Marc Aury, Klaus Valentin, Bernard Kloareg, Bernard Kloareg, Pi Nyvall-Collén, Pi Nyvall-Collén, Gaelle Samson, Catherine Boyen, Catherine Boyen, Gildas Le Corguillé, Bernhard Gschloessl, Bernhard Gschloessl, Diego Miranda-Saavedra, Kenny Billiau, Nicolas Delaroque, Jonas Collén, Jonas Collén, Andrew E. Allen, Susana M. Coelho, Susana M. Coelho, Declan C. Schroeder, Béatrice Segurens, Aude Le Bail, Aude Le Bail, Kei Kimura, Lieven Sterck, Sylvie Rousvoal, Sylvie Rousvoal, Cyril Pommier   +118 more
openaire   +5 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

The Collaborative African Genomics Network (CAfGEN): Applying Genomic technologies to probe host factors important to the progression of HIV and HIV-tuberculosis infection in sub-Saharan Africa [version 1; peer review: 2 approved]

AAS Open Research, 2018
Background: The Human Heredity and Health in Africa consortium (H3Africa) was conceived to facilitate the application of genomics technologies to improve health across Africa.
Gerald Mboowa, Savannah Mwesigwa, Eric Katagirya, Gaone Retshabile, Busisiwe C. Mlotshwa, Lesedi Williams, Adeodata Kekitiinwa, David Kateete, Eddie Wampande, Misaki Wayengera, Betty Nsangi Kintu, Grace P. Kisitu, Samuel Kyobe, Chester W. Brown, Neil A. Hanchard, Graeme Mardon, Moses Joloba, Gabriel Anabwani, Ed Pettitt, Masego Tsimako-Johnstone, Ishmael Kasvosve, Koketso Maplanka, Sununguko W. Mpoloka, Makhosazana Hlatshwayo, Mogomotsi Matshaba   +24 more
doaj   +1 more source

Whole-Genome Sequence of the Trypoxylus dichotomus Japanese rhinoceros beetle [PDF]

arXiv, 2020
The draft whole-genome sequence of the Japanese rhinoceros beetle, Trypoxylus dichotomus was obtained using long-read PacBio sequence technology. The final assembled genome consisted of 739 Mbp in 2,347 contigs, with 24.5x mean coverage and a G+C content of 35.99%.
arxiv