Results 81 to 90 of about 860,476 (247)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington disease [PDF]

, 2020
Galen E.B. Wright, Nicholas S. Caron, Bernard Ng, Lorenzo Casal, William Casazza, Xiaohong Xu, Jolene Ooi, Mahmoud A. Pouladi, Sara Mostafavi, Colin J.D. Ross, Michael R. Hayden   +10 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Genomics and Public Health: Development of Web-based Training

Preventing Chronic Disease, 2005
In 2001, the Centers for Disease Control and Prevention funded three Centers for Genomics and Public Health to develop training tools for increasing genomic awareness.
Janice V. Bach, MS, Aaron Goldenberg, MA, MPH, Toby Citrin, JD, Sarah F. Raup, MPH, Jennifer Bodzin, MPH, Sharon L.R. Kardia, PhD   +5 more
doaj  

Selection on Expected Maximum Haploid Breeding Values Can Increase Genetic Gain in Recurrent Genomic Selection [PDF]

, 2018
Dominik Müller, Pascal Schopp, Albrecht E. Melchinger   +2 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Big Data: Astronomical or Genomical?

PLoS Biology, 2015
Genomics is a Big Data science and is going to get much bigger, very soon, but it is not known whether the needs of genomics will exceed other Big Data domains.
Zachary D Stephens, Skylar Y Lee, Faraz Faghri, Roy H Campbell, Chengxiang Zhai, Miles J Efron, Ravishankar Iyer, Michael C Schatz, Saurabh Sinha, Gene E Robinson   +9 more
doaj   +1 more source

Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue [PDF]

, 2012
David J. Monsma, Noel R. Monks, David Cherba, Dawna Dylewski, Emily Eugster, Hailey Jahn, Sujata Srikanth, Stephanie B. Scott, Patrick J. Richardson, Robin E. Everts, Aleksandr Ishkin, Yuri Nikolsky, James H. Resau, Robert E. Sigler, Brian J. Nickoloff, Craig P. Webb   +15 more
openalex   +1 more source

Sarcoptic mange severity is associated with reduced genomic variation and evidence of selection in Yellowstone National Park wolves (Canis lupus) [PDF]

, 2020
Alexandra L. DeCandia, Edward C. Schrom, Ellen E. Brandell, Daniel R. Stahler, Bridgett M. vonHoldt   +4 more
openalex   +1 more source