Results 1 to 10 of about 7,912 (88)

CDK7 as a Potential Exploratory Biomarker for Distinguishing Acute Myocardial. [PDF]

Clin Cardiol
Clinical Cardiology, Volume 49, Issue 6, June 2026.
Mehmood A, Tahir R.
europepmc   +2 more sources

Influence of Age and Exposure Pathway on Copper and Cadmium Mixture Toxicity: A Study on Daphnia magna

Environmental Toxicology, EarlyView.
ABSTRACT Metal contamination in aquatic ecosystems poses substantial risks to freshwater organisms, with mixture effects often deviating from predictions based on single‐metal toxicity. Understanding how age‐specific sensitivities and multiple exposure pathways influence mixture effects is critical for accurate risk assessment.
Sanah Majid, Karen Smeets, Mubiana K. Valentine, Ronny Blust   +3 more
wiley   +1 more source

sGC stimulator BAY 41‐8543 improves survival and ventricular function in a rat model of doxorubicin‐induced cardiomyopathy with nephrotic syndrome

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anthracyclines such as doxorubicin (DOXO) remain a cornerstone of cancer therapy but are associated with a high risk of cardiotoxicity and subsequent heart failure (HF). Impairment of NO/soluble guanylyl cyclase (sGC)/cGMP pathway has been reported in anthracycline‐induced cardiomyopathy.
Olga Gawrys, Petra Škaroupková, Soňa Kikerlová, Zdeňka Vaňourková, Martina Hüttl, Olga Lenčová, Kasin Yadunandam Anandam, Svenja Stomberg, Sönke Behrends, Barbara Szeiffová Bačová, Matúš Sykora, Lisa Dietz, Peter Sandner, Luděk Červenka, Martin Štěrba   +14 more
wiley   +1 more source

Fluvastatin Plus Dipyridamole Suppresses Canine Hemangiosarcoma Growth in Patient‐Derived Xenograft Models Through Lactate Dehydrogenase‐Associated Cholesterol/Lipid Metabolism

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Tumour cells commonly exhibit aerobic glycolysis and produce lactate despite oxygen availability. Lactate dehydrogenase (LDH) catalyses pyruvate‐lactate interconversion and regulates intracellular lactate levels. Endothelial cells also depend on glycolysis for ATP production, which prompted us to investigate LDH in canine hemangiosarcoma (HSA),
Tamami Suzuki, Suzune Tanaka, Keika Kishimoto, Takuma Goto, Jumpei Yamazaki, Takashi Kimura, Keisuke Aoshima   +6 more
wiley   +1 more source

Cross‐Talk Between Histamine H2 Receptor and Glucocorticoid Receptor: Potential Implications in Acute Myeloid Leukemia Treatment

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT This study investigates the impact of histamine H2 receptor activation on glucocorticoid receptor (GR)‐mediated transcriptional activity, as well as its effects on leukemic cell proliferation and chemotherapy resistance. We demonstrate that activation of the histamine H2 receptor by its specific agonist, amthamine, enhances GR transcriptional ...
Valeria Torralba‐Agu, Natalia Fernández, Carina Shayo, Carlos Davio, C. Daniel Zappia, Federico Monczor   +5 more
wiley   +1 more source

Loss of DET1 in High Pigment 2 Tomato Prevents High Temperature Repression of Anthocyanin Biosynthesis in Fruit Through HY5 Stabilization

Plant, Cell &Environment, Volume 49, Issue 10, Page 7449-7469, October 2026.
ABSTRACT Global warming impacts several aspects of plant physiology, with important negative effects on crop yield and production of secondary metabolites, such as anthocyanins. The anthocyanin content of vegetables and fruits has attracted public interest in the last two decades due to its health benefits, leading to the development of novel ...
Jacopo Menconi, Noemi La Monaca, Irene Cataldo, Pietro Maria Niccolini, Pierdomenico Perata, Silvia Gonzali   +5 more
wiley   +1 more source

A symmetric systemic challenge elicits a right‐biased response mediated by vasopressin signaling

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Water deprivation, a spatially symmetric homeostatic challenge, induces vasopressin receptor‐dependent right‐sided hindlimb asymmetry in rats, providing a binary readout of lateralized physiological regulation. These findings suggest that symmetric homeostatic challenges can engage neuroendocrine mechanisms that shift the balance between left‐ and ...
Hiroyuki Watanabe, Yaromir Kobikov, Sara Yusuf Mohamed, Karen Rich, Daniil Sarkisyan, Olga Nosova, Alfhild Grönbladh, Mathias Hallberg, Jens Schouenborg, Georgy Bakalkin, Mengliang Zhang   +10 more
wiley   +1 more source

Messenger RNA From Canine Cytology Lymph Node Specimens Can Be Utilised for Gene Expression Profiling Using Digital RNA Counting

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 568-577, September 2026.
ABSTRACT Gene expression profiling (GEP) is being used with increasing frequency to characterise canine tumours, but canine samples are often not collected in a medium to preserve RNA. Cytology samples from human tumours have been shown to provide adequate RNA for GEP using NanoString nCounter technology, suggesting a similar approach might be viable ...
McKenzie Olsen, Emily Rout, Kelly Hughes, Janna Yoshimoto, Anne Avery, R. Adam Harris   +5 more
wiley   +1 more source

Survival Impact of Programmed Cell Death Ligand‐1 Expression in Patients With Epithelial Ovarian Carcinoma

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Aims To evaluate the proportion of expressed programmed cell death ligands‐1 (PD‐L1) in epithelial ovarian carcinoma patients, and the association with the clinicopathological, surgical outcomes, and oncologic outcomes. To compare PD‐L1 protein expression with messenger ribonucleic acid (mRNA) expression. Methods The patients who had pathology
Achjima Tankul, Suchanan Hanamornroongruang, Naravat Poungvarin, Rachawalan Suriyasaengsri, Sompop Kuljarusnont, Pornprom Ittiamornlert, Wathirada Karnchanabanyong, Irene Ruengkhachorn, Saowalak Hunnangkul   +8 more
wiley   +1 more source

Systemic and Local Adiposity in the Bone Marrow Microenvironment Associated With Improved Prognosis in Hodgkin Lymphoma: Imaging and Molecular Analysis

International Journal of Cancer, Volume 159, Issue 3, Page 782-796, 1 August 2026.
Schematic overview of systemic and bone marrow‐specific adiposity in Hodgkin Lymphoma (HL). Body Mass Index was associated with bone marrow (BM) involvement, relapse, and mortality (1). In contrast, increased yellow marrow density was associated with poorer prognosis (2).
Andreia Matos, William P. Cawthorn, Joana Marinho‐Dias, Sofia Ramalheira, Susana Roncon, Dulcineia Pereira, Teresa Ribeiro, Carla Rodrigues, Mário Mariz, Ana Miranda, Helena Brízido, Manuel Bicho, Pedro Medeiros, Ana Carneiro, Fernanda Trigo, Pingzhao Hu, Flávia Pereira, Hugo Duarte, Calum D. Gray, Tom Macgillivray, Alan G. Ramsay, Maria J. Oliveira, Ricardo Ribeiro   +22 more
wiley   +1 more source