Results 11 to 20 of about 63 (60)
Arastirmacilar son yillarda cevremizde hem insanlar tarafindan hem de dogal olarak meydana gelmis bircok mutajenin varligini net bir sekilde gostermislerdir. Hava ve sularin her ikisini de kirleten kimyasal ajanlar, gidalar, ilaclar, kozmetik urunleri, pestisitler, ev yapimi ve endustriyel kimyasallar gibi bircok kimyasal sinifini icermektedir ...
AKYIL, Dilek, ÖZKARA, Arzu
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The aim of this study is to investigate the genotoxic effects of ammonium sulphate and the protective role of βcarotene against genotoxicity in Swiss albino mice. Albino mice divided into one control group and five treatment groups. The body weight gain,
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doaj
Anastrozol kullanan hastalarda genotoksisite riski ve dna onarım kapasitelerinin araştırılması [PDF]
Breast cancer is the most common cancer in women worldwide with a increase of incidence in postmenopausal women. Anastrozole is considered type II, non-steroidal and third generation aromatase inhibitor (AI) that is used in the first line adjuvant endocrine therapy of postmenopausal breast cancer.
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Talasemi major (TM), hemoglobinin globin zincirlerinde yapım azlığı veya hiç yapılamaması sonucu ortaya çıkan hematolojik bir hastalıktır. Hastaların büyük bir kısmının eritrosit desteğiyle yaşamlarını sürdürmek zorunda kalmaları bazı komplikasyonların gelişmesine de yol açar. Bunu önlemek amacı ile organlarda birikmiş demiri atmak için ?desferroksamin
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Talasemi taşıyıcısı çocuklarda genotoksisite ve sitotoksisitenin sitom yöntemiyle değerlendirilmesi
Thalassemia is one of the hereditary hemoglobin disorders, the most common type is beta thalassemia. It is shown that genotoxicity risk is increased in beta thalassemia major patients. Until now there is no comprehensive study which the risk of genotoxicity in beta thalassemia (BT) minor individuals are evaluated and the data of these studies is ...
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Alkilleyici ajanlar tarafından uyarılan genotoksisite üzerine curcumin`in etkisi
DNA hasarı organizmaların yaşamı boyunca maruz kaldığı önemli bir genotoksik stres türüdür. Doğrudan etkili alkilleyici ajanlardan olan metil metansülfonat (MMS), DNA'ya kovalent olarak bağlanarak DNA'da hasar oluştururken, dolaylı yoldan etkili alkilleyici ajanlardan olan siklofosfamid (SP) ise hücresel proteinlerin fonksiyonlarını ...
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Aim: In this study, it is aimed to investigate genotoxicity and cytotoxicity of vildagliptin and sitagliptin active ingredients and their metabolites, used in the treatment of type 2 diabetes in in vitro culture conditions.Material and Method: Whole blood cultures were established with two male and two female healthy volunteers' blood.
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In our study, genotoxic effects of ionizing radiation which is a physical mutagen and radioprotective effects of quinic acid are evaluated. For this purpose in vitro COMET assay was carried out in human peripheral blood lymphocytes.Blood samples are drawn into tubes with heparin as an anticoagulant and lymphocytes are isolated.
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Genotoksisite testlerinin yeni ilaç geliştirme sürecindeki önemi
In the preclinic investigation period at the beginning of the drug development process, it is an obligation to subject candidate drugs to genotoxicty investigations. Genotoxicty data of drugs that are developed with these tests are demanded as a part of the security evaluation process by regulatory authorities in various countries.
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